MC4R

The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity.

Full Name

MELANOCORTIN 4 RECEPTOR

Function

Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).

Biological Process

Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: BHF-UCL
Adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: ProtInc
Diet induced thermogenesis Source: Ensembl
Energy reserve metabolic process Source: Ensembl
Feeding behavior Source: ProtInc
Insulin secretion Source: Ensembl
Negative regulation of feeding behavior Source: Ensembl
Positive regulation of bone resorption Source: HGNC-UCL
Regulation of eating behavior Source: ARUK-UCL
Regulation of grooming behavior Source: Ensembl
Regulation of metabolic process Source: GO_Central
Response to insulin Source: Ensembl
Response to melanocyte-stimulating hormone Source: ARUK-UCL

Cellular Location

Cell membrane

Involvement in disease

Obesity (OBESITY):
A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.

Topology

Extracellular: 1-43
Helical: 44-69
Cytoplasmic: 70-81
Helical: 82-106
Extracellular: 107-123
Helical: 124-145
Cytoplasmic: 146-165
Helical: 166-186
Extracellular: 187-191
Helical: 192-215
Cytoplasmic: 216-248
Helical: 249-271
Extracellular: 272-280
Helical: 281-304
Cytoplasmic: 305-332