METTL1

This gene is similar in sequence to the S. cerevisiae YDL201w gene. The gene product contains a conserved S-adenosylmethionine-binding motif and is inactivated by phosphorylation. Alternative splice variants encoding different protein isoforms have been described for this gene. A pseudogene has been identified on chromosome X. [provided by RefSeq, Jul 2008]

Full Name

Methyltransferase Like 1

Function

Methyltransferase that mediates the formation of N7-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs) (PubMed:12403464, PubMed:31031084, PubMed:31031083).

Catalyzes the formation of N7-methylguanine at position 46 (m7G46) in tRNA (PubMed:12403464, PubMed:31031084).

Also acts as a methyltransferase for a subset of internal N7-methylguanine in mRNAs (PubMed:31031084).

Internal N7-methylguanine methylation of mRNAs regulates translation (PubMed:31031084).

Also methylates a specific subset of miRNAs, such as let-7 (PubMed:31031083).

N7-methylguanine methylation of let-7 miRNA promotes let-7 miRNA processing by disrupting an inhibitory secondary structure within the primary miRNA transcript (pri-miRNA) (PubMed:31031083).

Acts as a regulator of embryonic stem cell self-renewal and differentiation (By similarity).

Biological Process

RNA (guanine-N7)-methylation Source: GO_Central
tRNA methylation Source: GO_Central
tRNA modification Source: UniProtKB

Cellular Location

Nucleus

PTM

Phosphorylation at Ser-27 inactivates its catalytic activity but does not affect the interaction with WDR4.