MEX3B

This gene encodes an RNA-binding phosphoprotein that is part of the MEX3 (muscle excess 3) family of translational regulators. The encoded protein contains N-terminal nuclear export and nuclear localization signals and is exported from the cytoplasm to the nucleus. The protein binds to RNA via two KH domains and also colocalizes with MEX3A, Dcp1A decapping factor and Argonaute proteins within P (processing) bodies.

MEX-3 RNA BINDING FAMILY MEMBER B

RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms.

Protein autophosphorylation Source: UniProtKB
Protein phosphorylation Source: UniProtKB

Cytoplasm
Nucleus
Other locations
P-body
Cytoplasmic granule
Note: Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. Localization to P-bodies is dependent on 14-3-3.

Phosphorylation at Ser-462 creates a docking site for 14-3-3, which stabilizes the protein and modulates its ability to bind RNA.