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Mouse Anti-MEX3B Recombinant Antibody (4C4) (CBMAB-A7617-LY)

The product is antibody recognizes RKHD3. The antibody 4C4 immunoassay techniques such as: WB, ELISA.
See all MEX3B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4C4
Antibody Isotype
IgG2b, κ
Application
WB, ELISA

Basic Information

Immunogen
RKHD3 (NP_115622, 60 a.a. ~ 159 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
MEX-3 RNA BINDING FAMILY MEMBER B
Entrez Gene ID
84206
UniProt ID
Q6ZN04
Alternative Names
DKFZp434J0617; MEX-3B; MGC117199; RKHD3; RNF195
Function
RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms.
Biological Process
Protein autophosphorylation Source: UniProtKB
Protein phosphorylation Source: UniProtKB
Cellular Location
Cytoplasm
Nucleus
Other locations
P-body
Cytoplasmic granule
Note: Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. Localization to P-bodies is dependent on 14-3-3.
PTM
Phosphorylation at Ser-462 creates a docking site for 14-3-3, which stabilizes the protein and modulates its ability to bind RNA.

Nan, C. A. (2023). The RNA-binding protein Mex3B regulates airway remodeling through modulation of TGFBR3 mRNA stability in chronic rhinosinusitis. The Journal of Immunology, 210(1_Supplement), 67-24.

Liu, J. X., Chen, A. N., Yu, Q., Shi, K. T., Liu, Y. B., Guo, C. L., ... & Liu, Z. (2023). MEX3B inhibits collagen production in eosinophilic nasal polyps by downregulating epithelial cell TGFBR3 mRNA stability. JCI insight, 8(9).

Hu, J., Xiang, Y., Zhu, X., Hu, C., Xu, X., Li, D., ... & Jiang, Z. (2023). Grass carp (Ctenopharyngodon idella) Mex3B positively regulates innate immunity by promoting the K63-linked ubiquitination of TLR3. Fish & Shellfish Immunology, 141, 109023.

Umehara, T., Mori, R., Murase, T., Tanaka, T., Kasai, K., Ikematsu, K., & Sato, H. (2022). rno-miR-203a-3p and Mex3B contribute to cell survival of iliopsoas muscle via the Socs3-Casp3 axis under severe hypothermia in rats. Legal Medicine, 59, 102150.

Yang, Y., Wang, S. Y., Li, Z. Q., & Wu, H. N. (2022). Mex3B inhibits DC-STAMP mRNA level and osteoclastogenesis. Cell Insight, 1(1), 100002.

Zou, J., Huang, Y., Wu, Z., Xie, H., Wang, R., & Xing, C. (2021). MEX3A and MEX3B as Potential Prognostic Indicators in Stomach Adenocarcinoma.

Liu, J. X., Liao, B., Yu, Q. H., Wang, H., Liu, Y. B., Guo, C. L., ... & Liu, Z. (2020). The IL-37–Mex3B–Toll-like receptor 3 axis in epithelial cells in patients with eosinophilic chronic rhinosinusitis with nasal polyps. Journal of Allergy and Clinical Immunology, 145(1), 160-172.

Umehara, T., Kagawa, S., Tomida, A., Murase, T., Abe, Y., Shingu, K., & Ikematsu, K. (2020). Body temperature-dependent microRNA expression analysis in rats: rno-miR-374-5p regulates apoptosis in skeletal muscle cells via Mex3B under hypothermia. Scientific Reports, 10(1), 15432.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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