Mouse Anti-MEX3B Recombinant Antibody (CBCNR-536) (CBMAB-R0583-CN)

Name: Mouse Anti-MEX3B Recombinant Antibody (CBCNR-536)
SKU: CBMAB-R0583-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBCNR-536

Application

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration

1 mg/mL

More Infomation

Target

Full Name

MEX-3 RNA BINDING FAMILY MEMBER B

Introduction

This gene encodes an RNA-binding phosphoprotein that is part of the MEX3 (muscle excess 3) family of translational regulators. The encoded protein contains N-terminal nuclear export and nuclear localization signals and is exported from the cytoplasm to the nucleus. The protein binds to RNA via two KH domains and also colocalizes with MEX3A, Dcp1A decapping factor and Argonaute proteins within P (processing) bodies. [provided by RefSeq, Oct 2012]

Entrez Gene ID

84206

UniProt ID

Q6ZN04

Alternative Names

Mex-3 RNA Binding Family Member B; Ring Finger And KH Domain Containing 3; RING Finger Protein 195; RNF195; RKHD3; RING Finger And KH Domain-Containing Protein 3;

Function

RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms.

Biological Process

Protein autophosphorylation Source: UniProtKB
Protein phosphorylation Source: UniProtKB

Cellular Location

Cytoplasm
Nucleus
Other locations
P-body
Cytoplasmic granule
Note: Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. Localization to P-bodies is dependent on 14-3-3.

PTM

Phosphorylation at Ser-462 creates a docking site for 14-3-3, which stabilizes the protein and modulates its ability to bind RNA.

Nan, C. A. (2023). The RNA-binding protein Mex3B regulates airway remodeling through modulation of TGFBR3 mRNA stability in chronic rhinosinusitis. The Journal of Immunology, 210(1_Supplement), 67-24.

Liu, J. X., Chen, A. N., Yu, Q., Shi, K. T., Liu, Y. B., Guo, C. L., ... & Liu, Z. (2023). MEX3B inhibits collagen production in eosinophilic nasal polyps by downregulating epithelial cell TGFBR3 mRNA stability. JCI insight, 8(9).

Hu, J., Xiang, Y., Zhu, X., Hu, C., Xu, X., Li, D., ... & Jiang, Z. (2023). Grass carp (Ctenopharyngodon idella) Mex3B positively regulates innate immunity by promoting the K63-linked ubiquitination of TLR3. Fish & Shellfish Immunology, 141, 109023.

Umehara, T., Mori, R., Murase, T., Tanaka, T., Kasai, K., Ikematsu, K., & Sato, H. (2022). rno-miR-203a-3p and Mex3B contribute to cell survival of iliopsoas muscle via the Socs3-Casp3 axis under severe hypothermia in rats. Legal Medicine, 59, 102150.

Yang, Y., Wang, S. Y., Li, Z. Q., & Wu, H. N. (2022). Mex3B inhibits DC-STAMP mRNA level and osteoclastogenesis. Cell Insight, 1(1), 100002.

Zou, J., Huang, Y., Wu, Z., Xie, H., Wang, R., & Xing, C. (2021). MEX3A and MEX3B as Potential Prognostic Indicators in Stomach Adenocarcinoma.

Liu, J. X., Liao, B., Yu, Q. H., Wang, H., Liu, Y. B., Guo, C. L., ... & Liu, Z. (2020). The IL-37–Mex3B–Toll-like receptor 3 axis in epithelial cells in patients with eosinophilic chronic rhinosinusitis with nasal polyps. Journal of Allergy and Clinical Immunology, 145(1), 160-172.

Umehara, T., Kagawa, S., Tomida, A., Murase, T., Abe, Y., Shingu, K., & Ikematsu, K. (2020). Body temperature-dependent microRNA expression analysis in rats: rno-miR-374-5p regulates apoptosis in skeletal muscle cells via Mex3B under hypothermia. Scientific Reports, 10(1), 15432.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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