MGP

This gene encodes a member of the osteocalcin/matrix Gla family of proteins. The encoded vitamin K-dependent protein is secreted by chondrocytes and vascular smooth muscle cells, and functions as a physiological inhibitor of ectopic tissue calcification. Carboxylation status of the encoded protein is associated with calcification of the vasculature in human patients with cardiovascular disease and calcification of the synovial membranes in osteoarthritis patients. Mutations in this gene cause Keutel syndrome in human patients, which is characterized by abnormal cartilage calcification, peripheral pulmonary stenosis and facial hypoplasia. [provided by RefSeq, Sep 2016]
Full Name
Matrix Gla Protein
Function
Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.
Biological Process
Cartilage condensation Source: ProtInc
Cell differentiation Source: UniProtKB-KW
Ossification Source: ProtInc
Regulation of bone mineralization Source: InterPro
Cellular Location
Secreted
Involvement in disease
Keutel syndrome (KTLS):
An autosomal recessive disorder characterized by abnormal cartilage calcification, peripheral pulmonary stenosis neural hearing loss and midfacial hypoplasia.
PTM
Requires vitamin K-dependent gamma-carboxylation for its function.
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Anti-MGP antibodies

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Mouse Anti-MGP Recombinant Antibody (A1082) (CBMAB-AP11851LY)

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Target: MGP
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: A1082
Application*: ELISA, IHC, WB
Datasheet SDS

Mouse Anti-MGP (AA 3-15) Recombinant Antibody (CBFYM-2187) (CBMAB-M2369-FY)

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Target: MGP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2187
Application*: IF, P, IP, WB
Datasheet SDS

Mouse Anti-MGP Recombinant Antibody (CF287) (CBMAB-FT214LY)

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Target: MGP
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CF287
Application*: ELISA, IHC, WB
Datasheet SDS

Rat Mgp ELISA Kit (V2LY-0626-LY3077)

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Target: Mgp
Sensitivity: 0.101 ng/mL
Detection Range: 0.2-70 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Rat
Assay Type: Sandwich
Reactivity: Rat
Datasheet SDS

Mouse Mgp ELISA Kit (V2LY-0626-LY1963)

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Target: Mgp
Sensitivity: 0.0031 ng/mL
Detection Range: 0.005-2 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Datasheet SDS

Human MGP ELISA Kit (V2LY-0626-LY1517)

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Target: MGP
Sensitivity: 0.0099 ng/mL
Detection Range: 0.02-6 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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