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Mouse Anti-MGP (AA 3-15) Recombinant Antibody (CBFYM-2187) (CBMAB-M2369-FY)

This product is mouse antibody that recognizes MGP. The antibody CBFYM-2187 can be used for immunoassay techniques such as: IF, IHC-P, IP, WB.
See all MGP antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2187
Antibody Isotype
IgG1
Application
IF, IHC-P, IP, WB

Basic Information

Immunogen
Synthetic peptide corresponding to aa 3-15 of non-phosphorylated human MGP (matrix Gla protein)
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
0.1% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 3-15

Target

Full Name
Matrix Gla Protein
Introduction
This gene encodes a member of the osteocalcin/matrix Gla family of proteins. The encoded vitamin K-dependent protein is secreted by chondrocytes and vascular smooth muscle cells, and functions as a physiological inhibitor of ectopic tissue calcification. Carboxylation status of the encoded protein is associated with calcification of the vasculature in human patients with cardiovascular disease and calcification of the synovial membranes in osteoarthritis patients. Mutations in this gene cause Keutel syndrome in human patients, which is characterized by abnormal cartilage calcification, peripheral pulmonary stenosis and facial hypoplasia.
Entrez Gene ID
4256
UniProt ID
P08493
Alternative Names
Matrix Gla Protein; Cell Growth-Inhibiting Gene 36 Protein; MGLAP; GIG36; NTI
Function
Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.
Biological Process
Cartilage condensation Source: ProtInc
Cell differentiation Source: UniProtKB-KW
Ossification Source: ProtInc
Regulation of bone mineralization Source: InterPro
Cellular Location
Secreted
Involvement in disease
Keutel syndrome (KTLS):
An autosomal recessive disorder characterized by abnormal cartilage calcification, peripheral pulmonary stenosis neural hearing loss and midfacial hypoplasia.
PTM
Requires vitamin K-dependent gamma-carboxylation for its function.

Malhotra, R., Nicholson, C. J., Wang, D., Bhambhani, V., Paniagua, S., Slocum, C., ... & Ho, J. E. (2022). Matrix Gla protein levels are associated with arterial stiffness and incident heart failure with preserved ejection fraction. Arteriosclerosis, Thrombosis, and Vascular Biology, 42(2), e61-e73.

Du, T., Pan, L., Zheng, C., Chen, K., Yang, Y., Chen, J., ... & Sun, P. (2022). Matrix Gla protein (MGP), GATA3, and TRPS1: a novel diagnostic panel to determine breast origin. Breast Cancer Research, 24(1), 1-17.

Kumric, M., Borovac, J. A., Ticinovic Kurir, T., Martinovic, D., Frka Separovic, I., Baric, L., & Bozic, J. (2021). Role of Matrix Gla Protein in the complex network of coronary artery disease: a comprehensive review. Life, 11(8), 737.

Roumeliotis, S., Dounousi, E., Salmas, M., Eleftheriadis, T., & Liakopoulos, V. (2020). Vascular calcification in chronic kidney disease: the role of vitamin K-dependent matrix Gla protein. Frontiers in medicine, 7, 154.

Bjørklund, G., Svanberg, E., Dadar, M., Card, D. J., Chirumbolo, S., Harrington, D. J., & Aaseth, J. (2020). The role of matrix Gla protein (MGP) in vascular calcification. Current Medicinal Chemistry, 27(10), 1647-1660.

Li, C., Li, J., He, F., Li, K., Li, X., & Zhang, Y. (2020). Matrix Gla protein regulates adipogenesis and is serum marker of visceral adiposity. Adipocyte, 9(1), 68-76.

Roumeliotis, S., Dounousi, E., Eleftheriadis, T., & Liakopoulos, V. (2019). Association of the inactive circulating matrix Gla protein with vitamin K intake, calcification, mortality, and cardiovascular disease: a review. International journal of molecular sciences, 20(3), 628.

Wei, F. F., Trenson, S., Verhamme, P., Vermeer, C., & Staessen, J. A. (2019). Vitamin K–dependent matrix Gla protein as multifaceted protector of vascular and tissue integrity. Hypertension, 73(6), 1160-1169.

Shepherd, C., Reese, A. E., Reynard, L. N., & Loughlin, J. (2019). Expression analysis of the osteoarthritis genetic susceptibility mapping to the matrix Gla protein gene MGP. Arthritis research & therapy, 21(1), 1-9.

Zhang, J., Ma, Z., Yan, K., Wang, Y., Yang, Y., & Wu, X. (2019). Matrix Gla protein promotes the bone formation by up-regulating Wnt/β-catenin signaling pathway. Frontiers in Endocrinology, 10, 891.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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