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MLLT10

This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
Full Name
MLLT10, Histone Lysine Methyltransferase DOT1L Cofactor
Function
Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302).
Biological Process
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
Involvement in disease
A chromosomal aberration involving MLLT10 is associated with acute leukemias. Translocation t(10;11)(p12;q23) with KMT2A/MLL1. The result is a rogue activator protein.
A chromosomal aberration involving MLLT10 is associated with diffuse histiocytic lymphomas. Translocation t(10;11)(p13;q14) with PICALM.
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Anti-MLLT10 antibodies

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Mouse Anti-MLLT10 Recombinant Antibody (CAP998) (CBMAB-AP184LY)

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Target: MLLT10
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CAP998
Application*: ELISA, IHC, WB
Datasheet SDS

Mouse Anti-MLLT10 Recombinant Antibody (9A5/2) (CBMAB-AP183LY)

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Target: MLLT10
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: 9A5/2
Application*: ELISA, FC, IHC, IP
Datasheet SDS

Mouse Anti-MLLT10 Recombinant Antibody (2B9) (CBMAB-A5516-LY)

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Target: MLLT10
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rat
Clone: 2B9
Application*: WB, E
Datasheet SDS

Recombinant Mouse Anti-MLLT10 Recombinant Antibody (9A5/2) (CBMAB-XB0817-YC)

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Target: MLLT10
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: 9A5/2
Application*: E, F, IH, IP, WB
Datasheet SDS

Recombinant Mouse Anti-MLLT10 Recombinant Antibody (10D3/8) (CBMAB-XB0816-YC)

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Target: MLLT10
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: 10D3/8
Application*: E, IH, IP, WB
Datasheet SDS

Mouse Anti-MLLT10 Recombinant Antibody (CBFYM-2303) (CBMAB-M2488-FY)

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Target: MLLT10
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-2303
Application*: E, F, IP, WB
Datasheet SDS

Mouse Anti-MLLT10 (AA 695-793) Recombinant Antibody (CBFYM-2302) (CBMAB-M2487-FY)

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Target: MLLT10
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-2302
Application*: E, WB
Datasheet SDS

Mouse Anti-MLLT10 Antibody (1D4) (CBMAB-0678-YC)

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Target: MLLT10
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1D4
Application*: IP, M
Datasheet SDS

Mouse Anti-MLLT10 Antibody (1C10) (CBMAB-0677-YC)

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Target: MLLT10
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1C10
Application*: IP, M
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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