Sign in or Register   Sign in or Register
  |  

MLLT10

This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
Full Name
MLLT10, Histone Lysine Methyltransferase DOT1L Cofactor
Function
Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302).
Biological Process
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
Involvement in disease
A chromosomal aberration involving MLLT10 is associated with acute leukemias. Translocation t(10;11)(p12;q23) with KMT2A/MLL1. The result is a rogue activator protein.
A chromosomal aberration involving MLLT10 is associated with diffuse histiocytic lymphomas. Translocation t(10;11)(p13;q14) with PICALM.

Anti-MLLT10 antibodies

Loading...

Mouse Anti-MLLT10 Recombinant Antibody (CBFYM-2303) (CBMAB-M2488-FY)

Datasheet SDS
Target: MLLT10
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-2303
Application*: E, F, IP, WB

Mouse Anti-MLLT10 (AA 695-793) Recombinant Antibody (CBFYM-2302) (CBMAB-M2487-FY)

Datasheet SDS
Target: MLLT10
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-2302
Application*: E, WB

Mouse Anti-MLLT10 Recombinant Antibody (CAP998) (CBMAB-AP184LY)

Datasheet SDS
Target: MLLT10
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CAP998
Application*: ELISA, IHC, WB

Mouse Anti-MLLT10 Recombinant Antibody (9A5/2) (CBMAB-AP183LY)

Datasheet SDS
Target: MLLT10
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: 9A5/2
Application*: ELISA, FC, IHC, IP

Mouse Anti-MLLT10 Recombinant Antibody (2B9) (CBMAB-A5516-LY)

Datasheet SDS
Target: MLLT10
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rat
Clone: 2B9
Application*: WB, E

Recombinant Mouse Anti-MLLT10 Recombinant Antibody (9A5/2) (CBMAB-XB0817-YC)

Datasheet SDS
Target: MLLT10
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: 9A5/2
Application*: E, F, IH, IP, WB

Recombinant Mouse Anti-MLLT10 Recombinant Antibody (10D3/8) (CBMAB-XB0816-YC)

Datasheet SDS
Target: MLLT10
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: 10D3/8
Application*: E, IH, IP, WB

Mouse Anti-MLLT10 Antibody (1D4) (CBMAB-0678-YC)

Datasheet SDS
Target: MLLT10
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1D4
Application*: IP, M

Mouse Anti-MLLT10 Antibody (1C10) (CBMAB-0677-YC)

Datasheet SDS
Target: MLLT10
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1C10
Application*: IP, M
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
Go to
Compare