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Mouse Anti-MLLT10 Recombinant Antibody (2B9) (CBMAB-A5516-LY)

The product is antibody recognizes MLLT10. The antibody 2B9 immunoassay techniques such as: WB, ELISA.
See all MLLT10 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
2B9
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
MLLT10 (NP_001009569, 695 a.a. ~ 793 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
MLLT10, Histone Lysine Methyltransferase DOT1L Cofactor
Entrez Gene ID
Human8028
Rat361285
UniProt ID
HumanP55197
RatF1M8I4
Alternative Names
AF10; DKFZp686E10210; MGC75086
Function
Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302).
Biological Process
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
Involvement in disease
A chromosomal aberration involving MLLT10 is associated with acute leukemias. Translocation t(10;11)(p12;q23) with KMT2A/MLL1. The result is a rogue activator protein.
A chromosomal aberration involving MLLT10 is associated with diffuse histiocytic lymphomas. Translocation t(10;11)(p13;q14) with PICALM.

Lin, H., Cossu, I. G., Leu, N. A., Deshpande, A. J., Bernt, K. M., Luo, M., & Wang, P. J. (2023). The DOT1L-MLLT10 complex regulates male fertility and promotes histone removal during spermiogenesis. Development, 150(9), dev201501.

Clifford, R., Munro, D., Dochtermann, D., Devineni, P., Pyarajan, S., Telese, F., ... & Friedman, R. (2023). Genome-wide association study of chronic dizziness in the elderly identifies loci implicating MLLT10, BPTF, LINC01224, and ROS1. Journal of the Association for Research in Otolaryngology, 1-17.

Kudo, K., Kubota, Y., Toki, T., Kanezaki, R., Kobayashi, A., Sato, T., ... & Terui, K. (2022). Childhood acute myeloid leukemia with 5q deletion and HNRNPH1-MLLT10 fusion: the first case report. Blood Advances, 6(10), 3162-3166.

Nilius-Eliliwi, V., Tembrink, M., Gerding, W. M., Lubieniecki, K. P., Lubieniecka, J. M., Kankel, S., ... & Vangala, D. B. (2022). Broad genomic workup including optical genome mapping uncovers a DDX3X: MLLT10 gene fusion in acute myeloid leukemia. Frontiers in Oncology, 12, 959243.

Yi, J., Peng, F., Zhao, J., & Gong, X. (2022). Prognostic Lnc-S100B-2 affects cell apoptosis and microenvironment of colorectal cancer through MLLT10 signaling. Journal of Oncology, 2022.

Yang, P., Zhang, Z., Xu, J., Qu, K., Lyv, S., Wang, X., ... & Huang, Y. (2020). The association of the copy number variation of the MLLT10 gene with growth traits of Chinese cattle. Animals, 10(2), 250.

Deutsch, J. L., & Heath, J. L. (2020). MLLT10 in benign and malignant hematopoiesis. Experimental Hematology, 87, 1-12.

Forgione, M. O., McClure, B. J., Yeung, D. T., Eadie, L. N., & White, D. L. (2020). MLLT10 rearranged acute leukemia: Incidence, prognosis, and possible therapeutic strategies. Genes, Chromosomes and Cancer, 59(12), 709-721.

Tian, Q. Q., Xia, J., Zhang, X., Gao, B. Q., & Wang, W. (2020). miR-331-3p inhibits tumor cell proliferation, metastasis, invasion by targeting MLLT10 in non-small cell lung cancer. Cancer Management and Research, 5749-5758.

Peterson, J. F., Sukov, W. R., Pitel, B. A., Smoley, S. A., Pearce, K. E., Meyer, R. G., ... & Ketterling, R. P. (2019). Acute leukemias harboring KMT2A/MLLT10 fusion: a 10‐year experience from a single genomics laboratory. Genes, Chromosomes and Cancer, 58(8), 567-577.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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