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Mouse Anti-MLLT10 Recombinant Antibody (CBFYM-2303) (CBMAB-M2488-FY)

This product is mouse antibody that recognizes MLLT10. The antibody CBFYM-2303 can be used for immunoassay techniques such as: ELISA, FC, IP, WB.
See all MLLT10 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2303
Antibody Isotype
IgG2b
Application
ELISA, FC, IP, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MLLT10, Histone Lysine Methyltransferase DOT1L Cofactor
Introduction
This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
8028
UniProt ID
P55197
Alternative Names
MLLT10, Histone Lysine Methyltransferase DOT1L Cofactor; Myeloid/Lymphoid Or Mixed-Lineage Leukemia; Translocated To, 10; ALL1-Fused Gene From Chromosome 10 Protein; AF10; Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax (Drosophila) Homolog); Translocated To, 10; Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila); Translocated To, 10
Function
Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302).
Biological Process
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
Involvement in disease
A chromosomal aberration involving MLLT10 is associated with acute leukemias. Translocation t(10;11)(p12;q23) with KMT2A/MLL1. The result is a rogue activator protein.
A chromosomal aberration involving MLLT10 is associated with diffuse histiocytic lymphomas. Translocation t(10;11)(p13;q14) with PICALM.

Lin, H., Cossu, I. G., Leu, N. A., Deshpande, A. J., Bernt, K. M., Luo, M., & Wang, P. J. (2023). The DOT1L-MLLT10 complex regulates male fertility and promotes histone removal during spermiogenesis. Development, 150(9), dev201501.

Clifford, R., Munro, D., Dochtermann, D., Devineni, P., Pyarajan, S., Telese, F., ... & Friedman, R. (2023). Genome-wide association study of chronic dizziness in the elderly identifies loci implicating MLLT10, BPTF, LINC01224, and ROS1. Journal of the Association for Research in Otolaryngology, 1-17.

Kudo, K., Kubota, Y., Toki, T., Kanezaki, R., Kobayashi, A., Sato, T., ... & Terui, K. (2022). Childhood acute myeloid leukemia with 5q deletion and HNRNPH1-MLLT10 fusion: the first case report. Blood Advances, 6(10), 3162-3166.

Nilius-Eliliwi, V., Tembrink, M., Gerding, W. M., Lubieniecki, K. P., Lubieniecka, J. M., Kankel, S., ... & Vangala, D. B. (2022). Broad genomic workup including optical genome mapping uncovers a DDX3X: MLLT10 gene fusion in acute myeloid leukemia. Frontiers in Oncology, 12, 959243.

Yi, J., Peng, F., Zhao, J., & Gong, X. (2022). Prognostic Lnc-S100B-2 affects cell apoptosis and microenvironment of colorectal cancer through MLLT10 signaling. Journal of Oncology, 2022.

Yang, P., Zhang, Z., Xu, J., Qu, K., Lyv, S., Wang, X., ... & Huang, Y. (2020). The association of the copy number variation of the MLLT10 gene with growth traits of Chinese cattle. Animals, 10(2), 250.

Deutsch, J. L., & Heath, J. L. (2020). MLLT10 in benign and malignant hematopoiesis. Experimental Hematology, 87, 1-12.

Forgione, M. O., McClure, B. J., Yeung, D. T., Eadie, L. N., & White, D. L. (2020). MLLT10 rearranged acute leukemia: Incidence, prognosis, and possible therapeutic strategies. Genes, Chromosomes and Cancer, 59(12), 709-721.

Tian, Q. Q., Xia, J., Zhang, X., Gao, B. Q., & Wang, W. (2020). miR-331-3p inhibits tumor cell proliferation, metastasis, invasion by targeting MLLT10 in non-small cell lung cancer. Cancer Management and Research, 5749-5758.

Peterson, J. F., Sukov, W. R., Pitel, B. A., Smoley, S. A., Pearce, K. E., Meyer, R. G., ... & Ketterling, R. P. (2019). Acute leukemias harboring KMT2A/MLLT10 fusion: a 10‐year experience from a single genomics laboratory. Genes, Chromosomes and Cancer, 58(8), 567-577.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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