MLLT11

The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia. t(1;11)(q21;q23) translocations that fused the MLL gene to a gene on chromosomal band 1q21 in 2 infants with acute myelomonocytic leukemia have been demonstrated. The N-terminal portion of the MLL gene is critical for leukemogenesis in translocations involving band 11q23. This gene encodes 90 amino acids. It was found to be highly expressed in the thymus but not in peripheral lymphoid tissues. In contrast to its restricted distribution in normal hematopoietic tissue, this gene was expressed in all leukemic cell lines tested.

Full Name

MLLT11, TRANSCRIPTION FACTOR 7 COFACTOR

Function

Cofactor for the transcription factor TCF7 (PubMed:26079538).

Involved in regulation of lymphoid development by driving multipotent hematopoietic progenitor cells towards a T cell fate (PubMed:21715312).

Biological Process

Extrinsic apoptotic signaling pathway Source: UniProtKB
Intrinsic apoptotic signaling pathway Source: UniProtKB
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of mitochondrial depolarization Source: UniProtKB
Positive regulation of release of cytochrome c from mitochondria Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB

Cellular Location

Cytoskeleton
centrosome
Cytoplasm
Nucleus
Note: Continuous nuclear export is followed by degradation.

Involvement in disease

A chromosomal aberration involving MLLT11 is found in acute leukemias. Translocation t(1;11)(q21;q23) with KMT2A/MLL1.

PTM

Ubiquitinated, leading to degradation.