Mouse Anti-MLLT11 Recombinant Antibody (CBFYM-2306) (CBMAB-M2491-FY)

Name: Mouse Anti-MLLT11 Recombinant Antibody (CBFYM-2306)
SKU: CBMAB-M2491-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-2306

Application

ELISA, ELISA(Cap), WB

Specificity

Human

Antibody Isotype

IgG2a, k

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

MLLT11, TRANSCRIPTION FACTOR 7 COFACTOR

Introduction

The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia. t translocations that fused the MLL gene to a gene on chromosomal band 1q21 in 2 infants with acute myelomonocytic leukemia have been demonstrated. The N-terminal portion of the MLL gene is critical for leukemogenesis in translocations involving band 11q23. This gene encodes 90 amino acids. It was found to be highly expressed in the thymus but not in peripheral lymphoid tissues. In contrast to its restricted distribution in normal hematopoietic tissue, this gene was expressed in all leukemic cell lines tested.

Entrez Gene ID

10962

UniProt ID

Q13015

Alternative Names

MLLT11, Transcription Factor 7 Cofactor; Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila); Translocated To, 11; Myeloid/Lymphoid Or Mixed-Lineage Leukemia; Translocated To, 11; ALL1 Fused Gene From Chromosome 1q; AF1Q; Protein AF1q

Function

Cofactor for the transcription factor TCF7 (PubMed:26079538).

Involved in regulation of lymphoid development by driving multipotent hematopoietic progenitor cells towards a T cell fate (PubMed:21715312).

Biological Process

Extrinsic apoptotic signaling pathway Source: UniProtKB
Intrinsic apoptotic signaling pathway Source: UniProtKB
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of mitochondrial depolarization Source: UniProtKB
Positive regulation of release of cytochrome c from mitochondria Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB

Cellular Location

Cytoskeleton
centrosome
Cytoplasm
Nucleus
Note: Continuous nuclear export is followed by degradation.

Involvement in disease

A chromosomal aberration involving MLLT11 is found in acute leukemias. Translocation t(1;11)(q21;q23) with KMT2A/MLL1.

PTM

Ubiquitinated, leading to degradation.

Blommers, M., Stanton-Turcotte, D., Witt, E. A., Heidari, M., & Iulianella, A. (2023). Cerebellar granule cell migration and folia development requires Mllt11/Af1q. bioRxiv, 2023-09.

Proestling, K., Husslein, H., Hudson, Q. J., Witzmann-Stern, M., Widmar, B., Bagó-Horváth, Z., ... & Yotova, I. (2023). MLLT11 Regulates Endometrial Stroma Cell Adhesion, Proliferation and Survival in Ectopic Lesions of Women with Advanced Endometriosis. International Journal of Molecular Sciences, 25(1), 439.

Blommers, M., Stanton‐Turcotte, D., & Iulianella, A. (2023). Retinal neuroblast migration and ganglion cell layer organization require the cytoskeletal‐interacting protein Mllt11. Developmental Dynamics, 252(2), 305-319.

Liu, X., Bai, W., Li, J., Ma, J., Liu, Y., Wang, Z., ... & Lu, X. (2023). MLLT11 siRNA Inhibits the Migration and Promotes the Apoptosis of MDA-MB-231 Breast Cancer Cells. The Breast Journal, 2023.

Stanton-Turcotte, D., Hsu, K., Moore, S. A., Yamada, M., Fawcett, J. P., & Iulianella, A. (2022). Mllt11 regulates migration and neurite outgrowth of cortical projection neurons during development. Journal of Neuroscience, 42(19), 3931-3948.

Chen, L., Xiong, Z., Zhao, H., Teng, C., Liu, H., Huang, Q., ... & Li, X. (2022). Identification of the novel prognostic biomarker, MLLT11, reveals its relationship with immune checkpoint markers in glioma. Frontiers in Oncology, 12, 889351.

Liao, J., Chen, H., Qi, M., Wang, J., & Wang, M. (2022). MLLT11-TRIL complex promotes the progression of endometrial cancer through PI3K/AKT/mTOR signaling pathway. Cancer biology & therapy, 23(1), 211-224.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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