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Mouse Anti-MLLT11 (AA 1-91) Recombinant Antibody (CBFYM-2304) (CBMAB-M2489-FY)

This product is mouse antibody that recognizes MLLT11. The antibody CBFYM-2304 can be used for immunoassay techniques such as: ELISA, WB.
See all MLLT11 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2304
Antibody Isotype
IgG2a, k
Application
ELISA, WB

Basic Information

Immunogen
Full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, k
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-91

Target

Full Name
MLLT11, TRANSCRIPTION FACTOR 7 COFACTOR
Introduction
The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia. t translocations that fused the MLL gene to a gene on chromosomal band 1q21 in 2 infants with acute myelomonocytic leukemia have been demonstrated. The N-terminal portion of the MLL gene is critical for leukemogenesis in translocations involving band 11q23. This gene encodes 90 amino acids. It was found to be highly expressed in the thymus but not in peripheral lymphoid tissues. In contrast to its restricted distribution in normal hematopoietic tissue, this gene was expressed in all leukemic cell lines tested.
Entrez Gene ID
10962
UniProt ID
Q13015
Alternative Names
MLLT11, Transcription Factor 7 Cofactor; Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila); Translocated To, 11; Myeloid/Lymphoid Or Mixed-Lineage Leukemia; Translocated To, 11; ALL1 Fused Gene From Chromosome 1q; AF1Q; Protein AF1q
Function
Cofactor for the transcription factor TCF7 (PubMed:26079538).

Involved in regulation of lymphoid development by driving multipotent hematopoietic progenitor cells towards a T cell fate (PubMed:21715312).
Biological Process
Extrinsic apoptotic signaling pathway Source: UniProtKB
Intrinsic apoptotic signaling pathway Source: UniProtKB
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of mitochondrial depolarization Source: UniProtKB
Positive regulation of release of cytochrome c from mitochondria Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Cellular Location
Cytoskeleton
centrosome
Cytoplasm
Nucleus
Note: Continuous nuclear export is followed by degradation.
Involvement in disease
A chromosomal aberration involving MLLT11 is found in acute leukemias. Translocation t(1;11)(q21;q23) with KMT2A/MLL1.
PTM
Ubiquitinated, leading to degradation.

Blommers, M., Stanton-Turcotte, D., Witt, E. A., Heidari, M., & Iulianella, A. (2023). Cerebellar granule cell migration and folia development requires Mllt11/Af1q. bioRxiv, 2023-09.

Proestling, K., Husslein, H., Hudson, Q. J., Witzmann-Stern, M., Widmar, B., Bagó-Horváth, Z., ... & Yotova, I. (2023). MLLT11 Regulates Endometrial Stroma Cell Adhesion, Proliferation and Survival in Ectopic Lesions of Women with Advanced Endometriosis. International Journal of Molecular Sciences, 25(1), 439.

Blommers, M., Stanton‐Turcotte, D., & Iulianella, A. (2023). Retinal neuroblast migration and ganglion cell layer organization require the cytoskeletal‐interacting protein Mllt11. Developmental Dynamics, 252(2), 305-319.

Liu, X., Bai, W., Li, J., Ma, J., Liu, Y., Wang, Z., ... & Lu, X. (2023). MLLT11 siRNA Inhibits the Migration and Promotes the Apoptosis of MDA-MB-231 Breast Cancer Cells. The Breast Journal, 2023.

Stanton-Turcotte, D., Hsu, K., Moore, S. A., Yamada, M., Fawcett, J. P., & Iulianella, A. (2022). Mllt11 regulates migration and neurite outgrowth of cortical projection neurons during development. Journal of Neuroscience, 42(19), 3931-3948.

Chen, L., Xiong, Z., Zhao, H., Teng, C., Liu, H., Huang, Q., ... & Li, X. (2022). Identification of the novel prognostic biomarker, MLLT11, reveals its relationship with immune checkpoint markers in glioma. Frontiers in Oncology, 12, 889351.

Liao, J., Chen, H., Qi, M., Wang, J., & Wang, M. (2022). MLLT11-TRIL complex promotes the progression of endometrial cancer through PI3K/AKT/mTOR signaling pathway. Cancer biology & therapy, 23(1), 211-224.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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