MMRN2

This gene encodes a protein belonging to the member of elastin microfibril interface-located (EMILIN) protein family. This family member is an extracellular matrix glycoprotein that can interfere with tumor angiogenesis and growth. It serves as a transforming growth factor beta antagonist and can interfere with the VEGF-A/VEGFR2 pathway. A related pseudogene has been identified on chromosome 6.

Full Name

MULTIMERIN 2

Function

Inhibits endothelial cells motility and acts as a negative regulator of angiogenesis; it down-regulates KDR activation by binding VEGFA.

Biological Process

Cell adhesion Source: ComplexPortal
Cell migration involved in sprouting angiogenesis Source: Ensembl
Negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis Source: ComplexPortal
Negative regulation of cell migration Source: ComplexPortal
Negative regulation of cell migration involved in sprouting angiogenesis Source: UniProtKB
Negative regulation of cell population proliferation Source: ComplexPortal
Negative regulation of vascular endothelial growth factor receptor signaling pathway Source: UniProtKB
Positive regulation of defense response to bacterium Source: Ensembl
Positive regulation of epithelial tube formation Source: ComplexPortal
Positive regulation of morphogenesis of an epithelium Source: ComplexPortal

Cellular Location

Extracellular matrix

PTM

N- and O-glycosylated.