Human MMRN2 ELISA Kit (V2LY-0626-LY5888)

Name: Human MMRN2 ELISA Kit
SKU: V2LY-0626-LY5888
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.026 ng/mL

Detection Range

0.05-20 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Human

Assay Type

Sandwich

Reactivity

Human

Assay Time

1.5 h

Molecule Mass

104.4 kDa

Components

Pre-coated ELISA Plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

MULTIMERIN 2

Function

Inhibits endothelial cells motility and acts as a negative regulator of angiogenesis; it down-regulates KDR activation by binding VEGFA.

Biological Process

Cell adhesion Source: ComplexPortal
Cell migration involved in sprouting angiogenesis Source: Ensembl
Negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis Source: ComplexPortal
Negative regulation of cell migration Source: ComplexPortal
Negative regulation of cell migration involved in sprouting angiogenesis Source: UniProtKB
Negative regulation of cell population proliferation Source: ComplexPortal
Negative regulation of vascular endothelial growth factor receptor signaling pathway Source: UniProtKB
Positive regulation of defense response to bacterium Source: Ensembl
Positive regulation of epithelial tube formation Source: ComplexPortal
Positive regulation of morphogenesis of an epithelium Source: ComplexPortal

Cellular Location

Extracellular matrix

PTM

N- and O-glycosylated.

Li, Y., Fu, L., Wu, B., Guo, X., Shi, Y., Lv, C., ... & Tian, Y. (2023). Angiogenesis modulated by CD93 and its natural ligands IGFBP7 and MMRN2: a new target to facilitate solid tumor therapy by vasculature normalization. Cancer Cell International, 23(1), 189.

Wang, X., Cui, Z., Chen, X., Luo, Q., Jiang, Z., Liu, X., ... & Zhuang, J. (2023). The CXCR4/miR-1910-5p/MMRN2 Axis Is Involved in Corneal Neovascularization by Affecting Vascular Permeability. Investigative Ophthalmology & Visual Science, 64(4), 10-10.

Neag, G. (2022). Targeting the novel CD248-MMRN2-CLEC14A pathway in age-related bone loss (Doctoral dissertation, University of Birmingham).

Liang, Q., Su, L., Zhang, D., & Jiao, J. (2020). CD93 negatively regulates astrogenesis in response to MMRN2 through the transcriptional repressor ZFP503 in the developing brain. Proceedings of the National Academy of Sciences, 117(17), 9413-9422.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-MMRN2 Recombinant Antibody (CBFYM-2431) (CAT#: CBMAB-M2618-FY)

Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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