Mouse Anti-MMRN2 Recombinant Antibody (CBFYM-2431) (CBMAB-M2618-FY)

This product is mouse antibody that recognizes MMRN2. The antibody CBFYM-2431 can be used for immunoassay techniques such as: FC, IHC-Fr, IP, WB.
See all MMRN2 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBFYM-2431

Antibody Isotype

IgG1

Application

FC, IHC-Fr, IP, WB

Basic Information

Immunogen

Purified human EndoGlyx-1 glycoprotein

Specificity

Human

Antibody Isotype

IgG1

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

MULTIMERIN 2

Introduction

This gene encodes a protein belonging to the member of elastin microfibril interface-located protein family. This family member is an extracellular matrix glycoprotein that can interfere with tumor angiogenesis and growth. It serves as a transforming growth factor beta antagonist and can interfere with the VEGF-A/VEGFR2 pathway. A related pseudogene has been identified on chromosome 6.

Entrez Gene ID

79812

UniProt ID

Q9H8L6

Alternative Names

Multimerin 2; Elastin Microfibril Interfacer 3; Elastin Microfibril Interface Located Protein 3; EndoGlyx-1 P125/P140 Subunit; EMILIN-3; EMILIN3; EMILIN-Like Protein EndoGlyx-1; Multimerin-2; ENDOGLYX-1

Function

Inhibits endothelial cells motility and acts as a negative regulator of angiogenesis; it down-regulates KDR activation by binding VEGFA.

Biological Process

Cell adhesion Source: ComplexPortal
Cell migration involved in sprouting angiogenesis Source: Ensembl
Negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis Source: ComplexPortal
Negative regulation of cell migration Source: ComplexPortal
Negative regulation of cell migration involved in sprouting angiogenesis Source: UniProtKB
Negative regulation of cell population proliferation Source: ComplexPortal
Negative regulation of vascular endothelial growth factor receptor signaling pathway Source: UniProtKB
Positive regulation of defense response to bacterium Source: Ensembl
Positive regulation of epithelial tube formation Source: ComplexPortal
Positive regulation of morphogenesis of an epithelium Source: ComplexPortal

Cellular Location

Extracellular matrix

PTM

N- and O-glycosylated.

References

Li, Y., Fu, L., Wu, B., Guo, X., Shi, Y., Lv, C., ... & Tian, Y. (2023). Angiogenesis modulated by CD93 and its natural ligands IGFBP7 and MMRN2: a new target to facilitate solid tumor therapy by vasculature normalization. Cancer Cell International, 23(1), 189.

Wang, X., Cui, Z., Chen, X., Luo, Q., Jiang, Z., Liu, X., ... & Zhuang, J. (2023). The CXCR4/miR-1910-5p/MMRN2 Axis Is Involved in Corneal Neovascularization by Affecting Vascular Permeability. Investigative Ophthalmology & Visual Science, 64(4), 10-10.

Neag, G. (2022). Targeting the novel CD248-MMRN2-CLEC14A pathway in age-related bone loss (Doctoral dissertation, University of Birmingham).

Liang, Q., Su, L., Zhang, D., & Jiao, J. (2020). CD93 negatively regulates astrogenesis in response to MMRN2 through the transcriptional repressor ZFP503 in the developing brain. Proceedings of the National Academy of Sciences, 117(17), 9413-9422.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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