MMS19

MMS19 (MMS19 Homolog, Cytosolic Iron-Sulfur Assembly Component) is a Protein Coding gene. Among its related pathways are Metabolism and Cytosolic iron-sulfur cluster assembly. Gene Ontology (GO) annotations related to this gene include binding and protein binding, bridging.

Full Name

MMS19 Homolog, Cytosolic Iron-Sulfur Assembly Component

Function

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity (PubMed:29848660).

In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER), homologous recombination-mediated double-strand break DNA repair, DNA replication and RNA polymerase II (POL II) transcription (PubMed:22678362, PubMed:22678361, PubMed:29225034, PubMed:23585563).

As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur (Fe-S) cluster assembly into ERCC2/XPD (PubMed:20797633).

Together with CIAO2, facilitates the transfer of Fe-S clusters to the motor protein KIF4A, which ensures proper localization of KIF4A to mitotic machinery components to promote the progression of mitosis (PubMed:29848660).

Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery (PubMed:11279242).

Biological Process

Cellular response to DNA damage stimulus Source: UniProtKB
Chromosome segregation Source: UniProtKB
DNA metabolic process Source: UniProtKB
DNA repair Source: UniProtKB
Iron-sulfur cluster assembly Source: UniProtKB
Nucleotide-excision repair Source: UniProtKB
Phosphorelay signal transduction system Source: UniProtKB
Positive regulation of double-strand break repair via homologous recombination Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Protein maturation by iron-sulfur cluster transfer Source: UniProtKB
Response to hormone Source: UniProtKB
Transcription, DNA-templated Source: UniProtKB

Cellular Location

Nucleus
Cytoskeleton
spindle
centrosome
Note: In mitosis, enriched on centrosomes during prophase, localizes to the spindle during metaphase and surrounds compacted spindle midzone microtubules during telophase.

PTM

Ubiquitinated; undergoes 'Lys-48'-linked polyubiquitination by MAGEF1-NSMCE1 ubiquitin ligase complex leading to proteasomal degradation.