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Rabbit Anti-MMS19 Recombinant Antibody (CBFYM-2432) (CBMAB-M2619-FY)

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Datasheet
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Basic Information

Host Animal
Rabbit
Clone
CBFYM-2432
Application
IP, WB
Immunogen
Synthetic peptide corresponding to residues surrounding Leu892 of human MMS19
Specificity
Human, Mouse, Rat
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
HEPES, pH 7.5, 0.15 M NaCl, 0.01% BSA, 50% glycerol
Preservative
0.02% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
MMS19 Homolog, Cytosolic Iron-Sulfur Assembly Component
Introduction
MMS19 is a Protein Coding gene. Among its related pathways are Metabolism and Cytosolic iron-sulfur cluster assembly. Gene Ontology annotations related to this gene include binding and protein binding, bridging.
Entrez Gene ID
Human64210
Mouse72199
Rat171124
UniProt ID
HumanQ96T76
MouseQ9D071
RatM0R6T4
Alternative Names
MMS19 Homolog, Cytosolic Iron-Sulfur Assembly Component; MMS19-Like Protein; MET18 Homolog; MMS19L; HMMS19; MMS19 Nucleotide Excision Repair Homolog (S. Cerevisiae); MMS19 Nucleotide Excision Repair Protein Homolog
Function
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity (PubMed:29848660).

In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER), homologous recombination-mediated double-strand break DNA repair, DNA replication and RNA polymerase II (POL II) transcription (PubMed:22678362, PubMed:22678361, PubMed:29225034, PubMed:23585563).

As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur (Fe-S) cluster assembly into ERCC2/XPD (PubMed:20797633).

Together with CIAO2, facilitates the transfer of Fe-S clusters to the motor protein KIF4A, which ensures proper localization of KIF4A to mitotic machinery components to promote the progression of mitosis (PubMed:29848660).

Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery (PubMed:11279242).
Biological Process
Cellular response to DNA damage stimulus Source: UniProtKB
Chromosome segregation Source: UniProtKB
DNA metabolic process Source: UniProtKB
DNA repair Source: UniProtKB
Iron-sulfur cluster assembly Source: UniProtKB
Nucleotide-excision repair Source: UniProtKB
Phosphorelay signal transduction system Source: UniProtKB
Positive regulation of double-strand break repair via homologous recombination Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Protein maturation by iron-sulfur cluster transfer Source: UniProtKB
Response to hormone Source: UniProtKB
Transcription, DNA-templated Source: UniProtKB
Cellular Location
Nucleus
Cytoskeleton
spindle
centrosome
Note: In mitosis, enriched on centrosomes during prophase, localizes to the spindle during metaphase and surrounds compacted spindle midzone microtubules during telophase.
PTM
Ubiquitinated; undergoes 'Lys-48'-linked polyubiquitination by MAGEF1-NSMCE1 ubiquitin ligase complex leading to proteasomal degradation.

Ren, D., Li, L., Wang, S., & Zuo, Y. (2023). The c-MYC transcription factor conduces to resistance to cisplatin by regulating MMS19 in bladder cancer cells. Tissue and Cell, 82, 102096.

Chippalkatti, R., Egger, B., & Suter, B. (2020). Mms19 promotes spindle microtubule assembly in Drosophila neural stem cells. PLoS genetics, 16(11), e1008913.

Chippalkatti, R., Egger, B., & Suter, B. (2020). Mms19 promotes spindle microtubule assembly in neural stem cells through two distinct pathways. bioRxiv, 2020-06.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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