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Mouse Anti-MMS19 Recombinant Antibody (A1163) (CBMAB-AP11923LY)

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Datasheet
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Basic Information

Host Animal
Mouse
Clone
A1163
Application
ELISA, IF, IHC, WB
Immunogen
Fusion protein of MMS19
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
Affinity purity
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
MMS19 Homolog, Cytosolic Iron-Sulfur Assembly Component
Introduction
MMS19 (MMS19 Homolog, Cytosolic Iron-Sulfur Assembly Component) is a Protein Coding gene. Among its related pathways are Metabolism and Cytosolic iron-sulfur cluster assembly. Gene Ontology (GO) annotations related to this gene include binding and protein binding, bridging.
Entrez Gene ID
Human64210
Mouse72199
Rat171124
UniProt ID
HumanQ96T76
MouseQ9D071
RatM0R6T4
Alternative Names
MMS19 Homolog, Cytosolic Iron-Sulfur Assembly Component; MMS19-Like Protein; MET18 Homolog; MMS19L; HMMS19; MMS19 Nucleotide Excision Repair Homolog (S. Cerevisiae); MMS19 Nucleotide Excision Repair Protein Homolog;
Function
E-AB-27247
Biological Process
Cellular response to DNA damage stimulus Source: UniProtKB
Chromosome segregation Source: UniProtKB
DNA metabolic process Source: UniProtKB
DNA repair Source: UniProtKB
Iron-sulfur cluster assembly Source: UniProtKB
Nucleotide-excision repair Source: UniProtKB
Phosphorelay signal transduction system Source: UniProtKB
Positive regulation of double-strand break repair via homologous recombination Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Protein maturation by iron-sulfur cluster transfer Source: UniProtKB
Response to hormone Source: UniProtKB
Transcription, DNA-templated Source: UniProtKB
Cellular Location
Nucleus
Cytoskeleton
spindle
centrosome
Note: In mitosis, enriched on centrosomes during prophase, localizes to the spindle during metaphase and surrounds compacted spindle midzone microtubules during telophase.
PTM
Ubiquitinated; undergoes 'Lys-48'-linked polyubiquitination by MAGEF1-NSMCE1 ubiquitin ligase complex leading to proteasomal degradation.

Ren, D., Li, L., Wang, S., & Zuo, Y. (2023). The c-MYC transcription factor conduces to resistance to cisplatin by regulating MMS19 in bladder cancer cells. Tissue and Cell, 82, 102096.

Chippalkatti, R., Egger, B., & Suter, B. (2020). Mms19 promotes spindle microtubule assembly in Drosophila neural stem cells. PLoS genetics, 16(11), e1008913.

Chippalkatti, R., Egger, B., & Suter, B. (2020). Mms19 promotes spindle microtubule assembly in neural stem cells through two distinct pathways. bioRxiv, 2020-06.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Recombinant Mouse Anti-MMS19 Recombinant Antibody (3H10) (CAT#: CBMAB-XB0828-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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