MRGPRX2

MRGPRX2 (MAS Related GPR Family Member X2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is MRGPRX3.

Full Name

MAS RELATED GPR FAMILY MEMBER X2

Function

Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core (PubMed:25517090).

Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction (By similarity).

Acts as a receptor for a number of other ligands, including peptides and alkaloids, such as cortistatin-14, proadrenomedullin N-terminal peptides PAMP-12 and, at lower extent, PAMP-20, antibacterial protein LL-37, PMX-53 peptide, beta-defensins, and complanadine A.

Biological Process

G protein-coupled receptor signaling pathway Source: GO_Central
Mast cell activation Source: UniProtKB
Mast cell degranulation Source: UniProtKB
Positive regulation of cytokinesis Source: UniProtKB
Sensory perception of pain Source: UniProtKB
Sleep Source: UniProtKB

Cellular Location

Cell membrane

Topology

Extracellular: 1-33
Helical: 34-54
Cytoplasmic: 55-63
Helical: 64-84
Extracellular: 85-96
Helical: 97-117
Cytoplasmic: 118-144
Helical: 145-165
Extracellular: 166-184
Helical: 185-205
Cytoplasmic: 206-228
Helical: 229-249
Extracellular: 250-264
Helical: 265-285
Cytoplasmic: 286-330