MSL2

MSL2 (MSL Complex Subunit 2) is a Protein Coding gene. Among its related pathways are Chromatin organization and Chromatin Regulation / Acetylation. Gene Ontology (GO) annotations related to this gene include ligase activity.
Full Name
MSL Complex Subunit 2
Function
Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1.
Biological Process
Histone H4-K16 acetylation Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: Ensembl
Protein ubiquitination Source: GO_Central
Regulation of dosage compensation by inactivation of X chromosome Source: Ensembl
Cellular Location
Nucleus
MSL complex
nucleoplasm
nucleus
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Anti-MSL2 antibodies

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Rabbit Anti-MSL2 Recombinant Antibody (D4V2N) (CBMAB-CP1589-LY)

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Target: MSL2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey, Cattle, Dog, Pig, Horse
Clone: D4V2N
Application*: WB, IP
Rabbit Anti-MSL2 Recombinant Antibody (D4V2N)
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Mouse Anti-MSL2 Recombinant Antibody (3A4) (CBMAB-A7662-LY)

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Target: MSL2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3A4
Application*: SE, E
Mouse Anti-MSL2 Recombinant Antibody (3A4)
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Mouse Anti-MSL2 Recombinant Antibody (4C5) (CBMAB-A5623-LY)

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Target: MSL2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4C5
Application*: SE, E
Mouse Anti-MSL2 Recombinant Antibody (4C5)
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Mouse Anti-MSL2 (AA 478-575) Recombinant Antibody (CBFYM-2643) (CBMAB-M2832-FY)

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Target: MSL2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-2643
Application*: E
Mouse Anti-MSL2 (AA 478-575) Recombinant Antibody (CBFYM-2643)
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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