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Rabbit Anti-MSL2 Recombinant Antibody (D4V2N) (CBMAB-CP1589-LY)

The product is antibody recognizes MSL2. The antibody D4V2N immunoassay techniques such as: WB,IP.
See all MSL2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey, Cattle, Dog, Pig, Horse
Clone
D4V2N
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro210 of human MSL2 protein.
Specificity
Human, Mouse, Rat, Monkey, Cattle, Dog, Pig, Horse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
MSL Complex Subunit 2
Introduction
MSL2 (MSL Complex Subunit 2) is a Protein Coding gene. Among its related pathways are Chromatin organization and Chromatin Regulation / Acetylation. Gene Ontology (GO) annotations related to this gene include ligase activity.
Entrez Gene ID
Human55167
Mouse77853
Rat315959
Dog485673
Monkey717049
Cattle525740
Pig100155763
Horse100065902
UniProt ID
HumanQ9HCI7
MouseQ69ZF8
RatD4A9S3
DogF1PLF9
MonkeyI0FT08
CattleF1MRF9
PigF1SL85
HorseF6QIX2
Alternative Names
MSL Complex Subunit 2; Male-Specific Lethal-2 Homolog 1; Male-Specific Lethal 2-Like 1; Ring Finger Protein 184; MSL2-Like 1; MSL2L1; RNF184; MSL-2; Male-Specific Lethal-2 Homolog (Drosophila);
Function
Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1.
Biological Process
Histone H4-K16 acetylation Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: Ensembl
Protein ubiquitination Source: GO_Central
Regulation of dosage compensation by inactivation of X chromosome Source: Ensembl
Cellular Location
Nucleus
MSL complex
nucleoplasm
nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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