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Mouse Anti-MSL2 (AA 478-575) Recombinant Antibody (CBFYM-2643) (CBMAB-M2832-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2643
Antibody Isotype
IgG1, k
Application
ELISA

Basic Information

Immunogen
Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 478-575

Target

Full Name
MSL Complex Subunit 2
Introduction
MSL2 is a Protein Coding gene. Among its related pathways are Chromatin organization and Chromatin Regulation/Acetylation. Gene Ontology annotations related to this gene include ligase activity.
Entrez Gene ID
55167
UniProt ID
Q9HCI7
Alternative Names
MSL Complex Subunit 2; Male-Specific Lethal-2 Homolog 1; Male-Specific Lethal 2-Like 1; Ring Finger Protein 184; MSL2-Like 1; MSL2L1; RNF184; MSL-2; Male-Specific Lethal-2 Homolog (Drosophila)
Function
Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1.
Biological Process
Histone H4-K16 acetylation Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: Ensembl
Protein ubiquitination Source: GO_Central
Regulation of dosage compensation by inactivation of X chromosome Source: Ensembl
Cellular Location
Nucleus
MSL complex
nucleoplasm
nucleus
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For research use only. Not intended for any clinical use.

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