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MYBL2

The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Transcript variants may exist for this gene, but their full-length natures have not been determined. [provided by RefSeq]

Full Name

v-myb myeloblastosis viral oncogene homolog (avian)-like 2

Function

Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene.

Biological Process

Cellular response to leukemia inhibitory factor Source: Ensembl
Mitotic cell cycle Source: GO_Central
Mitotic spindle assembly Source: Ensembl
Positive regulation of neuron apoptotic process Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription, DNA-templated Source: GO_Central

Cellular Location

Nucleus

PTM

Phosphorylated by cyclin A/CDK2 during S-phase. Phosphorylation at Thr-520 is probably involved in transcriptional activity.

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Anti-MYBL2 antibodies

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Mouse Anti-MYBL2 Recombinant Antibody (1C7) (CBMAB-A5705-LY)

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Target: MYBL2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1C7

Application*: WB, E

Mouse Anti-MYBL2 Recombinant Antibody (CBFYM-2873) (CBMAB-M3067-FY)

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Target: MYBL2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: CBFYM-2873

Application*: E, IC, WB

Mouse Anti-MYBL2 Recombinant Antibody (CBFYM-2872) (CBMAB-M3066-FY)

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Target: MYBL2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYM-2872

Application*: ELISA, WB

Mouse Anti-MYBL2 (AA 601-700) Recombinant Antibody (CBFYM-2871) (CBMAB-M3065-FY)

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Target: MYBL2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYM-2871

Application*: IF, WB

Rabbit Anti-MYBL2 (AA 1-538) Recombinant Antibody (CBYY-1140) (CBMAB-1144-YY)

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Target: MYBL2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human

Clone: CBYY-1140

Application*: WB, IP, P, F, CI, IC

Human MYBL2 ELISA Kit (V2LY-0626-LY4914)

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Target: MYBL2

Sensitivity: 0.0091 ng/mL

Detection Range: 0.02-4.5 ng/mL

Sample Type: Serum, Plasma, cell culture supernates

Specificity: Human

Assay Type: Sandwich

Reactivity: Human

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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