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Mouse Anti-MYBL2 Recombinant Antibody (1C7) (CBMAB-A5705-LY)

The product is antibody recognizes MYBL2. The antibody 1C7 immunoassay techniques such as: WB, ELISA.
See all MYBL2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1C7
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
MYBL2 (AAH53555, 601 a.a. ~ 700 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
v-myb myeloblastosis viral oncogene homolog (avian)-like 2
Introduction
The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Transcript variants may exist for this gene, but their full-length natures have not been determined. [provided by RefSeq]
Entrez Gene ID
4605
UniProt ID
P10244
Alternative Names
B-MYB; BMYB; MGC15600
Function
Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene.
Biological Process
Cellular response to leukemia inhibitory factor Source: Ensembl
Mitotic cell cycle Source: GO_Central
Mitotic spindle assembly Source: Ensembl
Positive regulation of neuron apoptotic process Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription, DNA-templated Source: GO_Central
Cellular Location
Nucleus
PTM
Phosphorylated by cyclin A/CDK2 during S-phase. Phosphorylation at Thr-520 is probably involved in transcriptional activity.

Liu, Q., Liu, H., Huang, X., Fan, X., Xiao, Z., Yan, R., ... & Liu, J. (2023). A targetable MYBL2-ATAD2 axis governs cell proliferation in ovarian cancer. Cancer Gene Therapy, 30(1), 192-208.

Liu, W., Shen, D., Ju, L., Zhang, R., Du, W., Jin, W., ... & Wang, X. (2022). MYBL2 promotes proliferation and metastasis of bladder cancer through transactivation of CDCA3. Oncogene, 41(41), 4606-4617.

Lee, Y., Wu, Z., Yang, S., Schreiner, S. M., Gonzalez-Smith, L. D., & Rhie, S. K. (2022). Characterizing and targeting genes regulated by transcription factor MYBL2 in lung adenocarcinoma cells. Cancers, 14(20), 4979.

Liu, Q., Guo, L., Qi, H., Lou, M., Wang, R., Hai, B., ... & Shao, J. (2021). A MYBL2 complex for RRM2 transactivation and the synthetic effect of MYBL2 knockdown with WEE1 inhibition against colorectal cancer. Cell Death & Disease, 12(7), 683.

Yu, S., Ai, L., Wei, W., & Pan, J. (2021). circRNA circ-MYBL2 is a novel tumor suppressor and potential biomarker in multiple myeloma. Human cell, 34, 219-228.

Li, Q., Wang, M., Hu, Y., Zhao, E., Li, J., Ren, L., ... & Ye, L. (2021). MYBL2 disrupts the Hippo-YAP pathway and confers castration resistance and metastatic potential in prostate cancer. Theranostics, 11(12), 5794.

Bayley, R., Ward, C., & Garcia, P. (2020). MYBL2 amplification in breast cancer: Molecular mechanisms and therapeutic potential. Biochimica et Biophysica Acta (BBA)-Reviews on Cancer, 1874(2), 188407.

Xiong, Y. C., Wang, J., Cheng, Y., Zhang, X. Y., & Ye, X. Q. (2020). Overexpression of MYBL2 promotes proliferation and migration of non-small-cell lung cancer via upregulating NCAPH. Molecular and Cellular Biochemistry, 468, 185-193.

Sun, Y. M., Wang, W. T., Zeng, Z. C., Chen, T. Q., Han, C., Pan, Q., ... & Chen, Y. Q. (2019). circMYBL2, a circRNA from MYBL2, regulates FLT3 translation by recruiting PTBP1 to promote FLT3-ITD AML progression. Blood, The Journal of the American Society of Hematology, 134(18), 1533-1546.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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