Human MYBL2 ELISA Kit (V2LY-0626-LY4914)

Name: Human MYBL2 ELISA Kit
SKU: V2LY-0626-LY4914
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.0091 ng/mL

Detection Range

0.02-4.5 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Human

Assay Type

Sandwich

Reactivity

Human

Assay Time

1.5 h

Molecule Mass

78.8 kDa

Components

Pre-coated ELISA Plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

v-myb myeloblastosis viral oncogene homolog (avian)-like 2

Function

Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene.

Biological Process

Cellular response to leukemia inhibitory factor Source: Ensembl
Mitotic cell cycle Source: GO_Central
Mitotic spindle assembly Source: Ensembl
Positive regulation of neuron apoptotic process Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription, DNA-templated Source: GO_Central

Cellular Location

Nucleus

PTM

Phosphorylated by cyclin A/CDK2 during S-phase. Phosphorylation at Thr-520 is probably involved in transcriptional activity.

Liu, Q., Liu, H., Huang, X., Fan, X., Xiao, Z., Yan, R., ... & Liu, J. (2023). A targetable MYBL2-ATAD2 axis governs cell proliferation in ovarian cancer. Cancer Gene Therapy, 30(1), 192-208.

Liu, W., Shen, D., Ju, L., Zhang, R., Du, W., Jin, W., ... & Wang, X. (2022). MYBL2 promotes proliferation and metastasis of bladder cancer through transactivation of CDCA3. Oncogene, 41(41), 4606-4617.

Lee, Y., Wu, Z., Yang, S., Schreiner, S. M., Gonzalez-Smith, L. D., & Rhie, S. K. (2022). Characterizing and targeting genes regulated by transcription factor MYBL2 in lung adenocarcinoma cells. Cancers, 14(20), 4979.

Liu, Q., Guo, L., Qi, H., Lou, M., Wang, R., Hai, B., ... & Shao, J. (2021). A MYBL2 complex for RRM2 transactivation and the synthetic effect of MYBL2 knockdown with WEE1 inhibition against colorectal cancer. Cell Death & Disease, 12(7), 683.

Yu, S., Ai, L., Wei, W., & Pan, J. (2021). circRNA circ-MYBL2 is a novel tumor suppressor and potential biomarker in multiple myeloma. Human cell, 34, 219-228.

Li, Q., Wang, M., Hu, Y., Zhao, E., Li, J., Ren, L., ... & Ye, L. (2021). MYBL2 disrupts the Hippo-YAP pathway and confers castration resistance and metastatic potential in prostate cancer. Theranostics, 11(12), 5794.

Bayley, R., Ward, C., & Garcia, P. (2020). MYBL2 amplification in breast cancer: Molecular mechanisms and therapeutic potential. Biochimica et Biophysica Acta (BBA)-Reviews on Cancer, 1874(2), 188407.

Xiong, Y. C., Wang, J., Cheng, Y., Zhang, X. Y., & Ye, X. Q. (2020). Overexpression of MYBL2 promotes proliferation and migration of non-small-cell lung cancer via upregulating NCAPH. Molecular and Cellular Biochemistry, 468, 185-193.

Sun, Y. M., Wang, W. T., Zeng, Z. C., Chen, T. Q., Han, C., Pan, Q., ... & Chen, Y. Q. (2019). circMYBL2, a circRNA from MYBL2, regulates FLT3 translation by recruiting PTBP1 to promote FLT3-ITD AML progression. Blood, The Journal of the American Society of Hematology, 134(18), 1533-1546.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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