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Rabbit Anti-MYBL2 (AA 1-538) Recombinant Antibody (CBYY-1140) (CBMAB-1144-YY)

This product is rabbit antibody that recognizes MYBL2. The antibody CBYY-1140 can be used for immunoassay techniques such as: WB, IP, IHC-P, FC, ChIP, ICC
See all MYBL2 antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
CBYY-1140
Antibody Isotype
IgG
Application
WB, IP, IHC-P, FC, ChIP, ICC

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-538

Target

Full Name
v-myb myeloblastosis viral oncogene homolog (avian)-like 2
Introduction
The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses Bovineth activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Two transcript variants encoding different isoforMouse have been found for this gene.
Entrez Gene ID
Human4605
Mouse17865
Rat296344
UniProt ID
HumanP10244
MouseP48972
RatD3ZLC6
Alternative Names
MYB Proto-Oncogene Like 2; V-Myb Avian Myeloblastosis Viral Oncogene Homolog-Like 2; Myb-Like Protein 2; B-MYB; BMYB; V-Myb Myeloblastosis Viral Oncogene Homolog-Like 2; Myb-Related Protein B;
Function
Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene.
Biological Process
Cellular response to leukemia inhibitory factor Source: Ensembl
Mitotic cell cycle Source: GO_Central
Mitotic spindle assembly Source: Ensembl
Positive regulation of neuron apoptotic process Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription, DNA-templated Source: GO_Central
Cellular Location
Nucleus
PTM
Phosphorylated by cyclin A/CDK2 during S-phase. Phosphorylation at Thr-520 is probably involved in transcriptional activity.

Liu, Q., Liu, H., Huang, X., Fan, X., Xiao, Z., Yan, R., ... & Liu, J. (2023). A targetable MYBL2-ATAD2 axis governs cell proliferation in ovarian cancer. Cancer Gene Therapy, 30(1), 192-208.

Liu, W., Shen, D., Ju, L., Zhang, R., Du, W., Jin, W., ... & Wang, X. (2022). MYBL2 promotes proliferation and metastasis of bladder cancer through transactivation of CDCA3. Oncogene, 41(41), 4606-4617.

Lee, Y., Wu, Z., Yang, S., Schreiner, S. M., Gonzalez-Smith, L. D., & Rhie, S. K. (2022). Characterizing and targeting genes regulated by transcription factor MYBL2 in lung adenocarcinoma cells. Cancers, 14(20), 4979.

Liu, Q., Guo, L., Qi, H., Lou, M., Wang, R., Hai, B., ... & Shao, J. (2021). A MYBL2 complex for RRM2 transactivation and the synthetic effect of MYBL2 knockdown with WEE1 inhibition against colorectal cancer. Cell Death & Disease, 12(7), 683.

Yu, S., Ai, L., Wei, W., & Pan, J. (2021). circRNA circ-MYBL2 is a novel tumor suppressor and potential biomarker in multiple myeloma. Human cell, 34, 219-228.

Li, Q., Wang, M., Hu, Y., Zhao, E., Li, J., Ren, L., ... & Ye, L. (2021). MYBL2 disrupts the Hippo-YAP pathway and confers castration resistance and metastatic potential in prostate cancer. Theranostics, 11(12), 5794.

Bayley, R., Ward, C., & Garcia, P. (2020). MYBL2 amplification in breast cancer: Molecular mechanisms and therapeutic potential. Biochimica et Biophysica Acta (BBA)-Reviews on Cancer, 1874(2), 188407.

Xiong, Y. C., Wang, J., Cheng, Y., Zhang, X. Y., & Ye, X. Q. (2020). Overexpression of MYBL2 promotes proliferation and migration of non-small-cell lung cancer via upregulating NCAPH. Molecular and Cellular Biochemistry, 468, 185-193.

Sun, Y. M., Wang, W. T., Zeng, Z. C., Chen, T. Q., Han, C., Pan, Q., ... & Chen, Y. Q. (2019). circMYBL2, a circRNA from MYBL2, regulates FLT3 translation by recruiting PTBP1 to promote FLT3-ITD AML progression. Blood, The Journal of the American Society of Hematology, 134(18), 1533-1546.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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