NEK11

This gene encodes a member of the never in mitosis gene A family of kinases. The encoded protein localizes to the nucleoli, and may function with NEK2A in the S-phase checkpoint. The encoded protein appears to play roles in DNA replication and response to genotoxic stress. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2009]
Full Name
NIMA Related Kinase 11
Function
Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation.
Biological Process
Chromosome segregation Source: GO_Central
Histone phosphorylation Source: CACAO
Intracellular signal transduction Source: UniProtKB
Mitotic intra-S DNA damage checkpoint signaling Source: UniProtKB
Protein phosphorylation Source: UniProtKB
Regulation of mitotic cell cycle phase transition Source: CACAO
Cellular Location
Nucleus
nucleolus
Note: Nuclear during interphase but moves to the polar microtubules during prometaphase and metaphase (PubMed:12154088). Accumulates in the nucleolus in G1/S-arrested cells (PubMed:15161910).
PTM
Phosphorylated by NEK2. Phosphorylation at Ser-273 is important for its activation.
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Anti-NEK11 antibodies

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Mouse Anti-NEK11 Recombinant Antibody (4E1-1F4) (CBMAB-A5869-LY)

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Target: NEK11
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4E1-1F4
Application*: WB, E
Datasheet SDS

Human Recombinant NEK11, Active protein, GST Tag (V2LY-0526-LY5735)

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Target: NEK11
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: Full Length
Tag: GST Tag
Datasheet SDS

NEK11 Matched Antibody Pair (790) (APMAB-790LY)

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Target: NEK11
Specificity: Human
Datasheet SDS

NEK11 Matched Antibody Pair (789) (APMAB-789LY)

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Target: NEK11
Specificity: Human
Datasheet SDS

Mouse Anti-NEK11 Recombinant Antibody (5D9) (CBMAB-N1920-WJ)

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Target: NEK11
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5D9
Application*: WB, IH, IF
Datasheet SDS

Mouse Anti-NEK11 Recombinant Antibody (4H5) (CBMAB-N1919-WJ)

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Target: NEK11
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4H5
Application*: WB, IF
Datasheet SDS

Mouse Anti-NEK11 Recombinant Antibody (CBWJN-0416) (CBMAB-N1918-WJ)

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Target: NEK11
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJN-0416
Application*: E, IF, IH, WB
Datasheet SDS

Mouse Anti-NEK11 Recombinant Antibody (5E9) (CBMAB-N1917-WJ)

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Target: NEK11
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5E9
Application*: F, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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