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NEK11

This gene encodes a member of the never in mitosis gene A family of kinases. The encoded protein localizes to the nucleoli, and may function with NEK2A in the S-phase checkpoint. The encoded protein appears to play roles in DNA replication and response to genotoxic stress. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2009]

Full Name

NIMA Related Kinase 11

Function

Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation.

Biological Process

Chromosome segregation Source: GO_Central
Histone phosphorylation Source: CACAO
Intracellular signal transduction Source: UniProtKB
Mitotic intra-S DNA damage checkpoint signaling Source: UniProtKB
Protein phosphorylation Source: UniProtKB
Regulation of mitotic cell cycle phase transition Source: CACAO

Cellular Location

Nucleus
nucleolus
Note: Nuclear during interphase but moves to the polar microtubules during prometaphase and metaphase (PubMed:12154088). Accumulates in the nucleolus in G1/S-arrested cells (PubMed:15161910).

PTM

Phosphorylated by NEK2. Phosphorylation at Ser-273 is important for its activation.

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Anti-NEK11 antibodies

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Mouse Anti-NEK11 Recombinant Antibody (4E1-1F4) (CBMAB-A5869-LY)

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Target: NEK11

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 4E1-1F4

Application*: WB, E

Human Recombinant NEK11, Active protein, GST Tag (V2LY-0526-LY5735)

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Target: NEK11

Expressed Host: Baculovirus-Insect Cells

Sequence: Amino Acid: Full Length

Tag: GST Tag

NEK11 Matched Antibody Pair (790) (APMAB-790LY)

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Target: NEK11

Specificity: Human

NEK11 Matched Antibody Pair (789) (APMAB-789LY)

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Target: NEK11

Specificity: Human

Mouse Anti-NEK11 Recombinant Antibody (5D9) (CBMAB-N1920-WJ)

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Target: NEK11

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 5D9

Application*: WB, IH, IF

Mouse Anti-NEK11 Recombinant Antibody (4H5) (CBMAB-N1919-WJ)

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Target: NEK11

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 4H5

Application*: WB, IF

Mouse Anti-NEK11 Recombinant Antibody (CBWJN-0416) (CBMAB-N1918-WJ)

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Target: NEK11

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBWJN-0416

Application*: E, IF, IH, WB

Mouse Anti-NEK11 Recombinant Antibody (5E9) (CBMAB-N1917-WJ)

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Target: NEK11

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 5E9

Application*: F, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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