Human Recombinant NEK11, Active protein, GST Tag (V2LY-0526-LY5735)

Name: Human Recombinant NEK11, Active protein, GST Tag
SKU: V2LY-0526-LY5735
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant NEK11, Active protein, GST Tag consist of Amino Acid: Full Length and predicts a molecular mass of 110 kDa.

Molecule Mass

110 kDa

Sequence

Amino Acid: Full Length

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

PBS

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

NIMA Related Kinase 11

Function

Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation.

Biological Process

Chromosome segregation Source: GO_Central
Histone phosphorylation Source: CACAO
Intracellular signal transduction Source: UniProtKB
Mitotic intra-S DNA damage checkpoint signaling Source: UniProtKB
Protein phosphorylation Source: UniProtKB
Regulation of mitotic cell cycle phase transition Source: CACAO

Cellular Location

Nucleus
nucleolus
Note: Nuclear during interphase but moves to the polar microtubules during prometaphase and metaphase (PubMed:12154088). Accumulates in the nucleolus in G1/S-arrested cells (PubMed:15161910).

PTM

Phosphorylated by NEK2. Phosphorylation at Ser-273 is important for its activation.

Christodoulou, E., van Doorn, R., Visser, M., Teunisse, A., Versluis, M., van der Velden, P., ... & Gruis, N. (2020). NEK11 as a candidate high-penetrance melanoma susceptibility gene. Journal of Medical Genetics, 57(3), 203-210.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

NEK11 Matched Antibody Pair (789) (CAT#: APMAB-789LY)

NEK11 Matched Antibody Pair (790) (CAT#: APMAB-790LY)

Antibody Pairs

NEK11 Matched Antibody Pair (789) (CAT#: APMAB-789LY)

NEK11 Matched Antibody Pair (790) (CAT#: APMAB-790LY)

Related Products

NEK11 Matched Antibody Pair (790) (CAT#: APMAB-790LY)

NEK11 Matched Antibody Pair (789) (CAT#: APMAB-789LY)

Mouse Anti-NEK11 Recombinant Antibody (4H5) (CAT#: CBMAB-N1919-WJ)

Mouse Anti-NEK11 Recombinant Antibody (5D9) (CAT#: CBMAB-N1920-WJ)

Mouse Anti-NEK11 Recombinant Antibody (5E9) (CAT#: CBMAB-N1917-WJ)

Mouse Anti-NEK11 Recombinant Antibody (4E1-1F4) (CAT#: CBMAB-A5869-LY)

Mouse Anti-NEK11 Recombinant Antibody (CBWJN-0416) (CAT#: CBMAB-N1918-WJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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