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Mouse Anti-NEK11 Recombinant Antibody (5E9) (CBMAB-N1917-WJ)

This product is a Mouse antibody that recognizes NEK11. The antibody 5E9 can be used for immunoassay techniques such as: FC, WB.
See all NEK11 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
5E9
Antibody Isotype
IgG1
Application
FC, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
0.76 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
NIMA Related Kinase 11
Introduction
This gene encodes a member of the never in mitosis gene A family of kinases. The encoded protein localizes to the nucleoli, and may function with NEK2A in the S-phase checkpoint. The encoded protein appears to play roles in DNA replication and response to genotoxic stress. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2009]
Entrez Gene ID
79858
UniProt ID
Q8NG66
Alternative Names
NIMA Related Kinase 11; NIMA (Never In Mitosis Gene A)- Related Kinase 11; Never In Mitosis A-Related Kinase 11; NimA-Related Protein Kinase 11; EC 2.7.11.1; EC 2.7.11;
Function
Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation.
Biological Process
Chromosome segregation Source: GO_Central
Histone phosphorylation Source: CACAO
Intracellular signal transduction Source: UniProtKB
Mitotic intra-S DNA damage checkpoint signaling Source: UniProtKB
Protein phosphorylation Source: UniProtKB
Regulation of mitotic cell cycle phase transition Source: CACAO
Cellular Location
Nucleus
nucleolus
Note: Nuclear during interphase but moves to the polar microtubules during prometaphase and metaphase (PubMed:12154088). Accumulates in the nucleolus in G1/S-arrested cells (PubMed:15161910).
PTM
Phosphorylated by NEK2. Phosphorylation at Ser-273 is important for its activation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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