NENF

This gene encodes a neurotrophic factor that may play a role in neuron differentiation and development. A pseudogene of this gene is found on chromosome 12. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2009]

Neudesin Neurotrophic Factor

Acts as a neurotrophic factor in postnatal mature neurons enhancing neuronal survival (PubMed:31536960).

Promotes cell proliferation and neurogenesis in undifferentiated neural progenitor cells at the embryonic stage and inhibits differentiation of astrocytes (By similarity).

Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways (By similarity).

Neurotrophic activity is enhanced by binding to heme (By similarity).

Acts also as an anorexigenic neurotrophic factor that contributes to energy balance (By similarity).

Negative regulation of appetite Source: UniProtKB
Negative regulation of neuron death Source: UniProtKB
Positive regulation of MAPK cascade Source: Ensembl

Mitochondrion
Endoplasmic reticulum
Extracellular region or secreted
extracellular space
Note: Localized to mitochondria and endoplasmic reticulum by PINK1 and PARK7.