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Mouse Anti-NENF Recombinant Antibody (4G9E12) (CBMAB-N1969-WJ)

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Basic Information

Host Animal
Mouse
Clone
4G9E12
Application
ELISA, WB, IHC, IF
Specificity
Human, Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
Neudesin Neurotrophic Factor
Introduction
This gene encodes a neurotrophic factor that may play a role in neuron differentiation and development. A pseudogene of this gene is found on chromosome 12. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2009]
Entrez Gene ID
Human29937
Mouse66208
UniProt ID
HumanQ9UMX5
MouseQ9CQ45
Alternative Names
Neudesin Neurotrophic Factor; Cell Immortalization-Related Protein 2; Secreted Protein Of Unknown Function; Neuron-Derived Neurotrophic Factor; Neudesin; CIR2; SPUF; Spinal Cord Injury Related Protein 10;
Function
Acts as a neurotrophic factor in postnatal mature neurons enhancing neuronal survival (PubMed:31536960).

Promotes cell proliferation and neurogenesis in undifferentiated neural progenitor cells at the embryonic stage and inhibits differentiation of astrocytes (By similarity).

Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways (By similarity).

Neurotrophic activity is enhanced by binding to heme (By similarity).

Acts also as an anorexigenic neurotrophic factor that contributes to energy balance (By similarity).
Biological Process
Negative regulation of appetite Source: UniProtKB
Negative regulation of neuron death Source: UniProtKB
Positive regulation of MAPK cascade Source: Ensembl
Cellular Location
Mitochondrion
Endoplasmic reticulum
Extracellular region or secreted
extracellular space
Note: Localized to mitochondria and endoplasmic reticulum by PINK1 and PARK7.

Kamińska, J., Koper-Lenkiewicz, O. M., Ponikwicka-Tyszko, D., Lebiedzińska, W., Palak, E., Sztachelska, M., ... & Dymicka-Piekarska, V. (2023). New Insights on the Progesterone (P4) and PGRMC1/NENF Complex Interactions in Colorectal Cancer Progression. Cancers, 15(20), 5074.

Li, A., Su, X., Wang, Y., Cheng, G., Zan, L., & Wang, H. (2020). Effect of neudesin neurotrophic factor on differentiation of bovine preadipocytes and myoblasts in a co-culture system. Animals, 11(1), 34.

Su, X., Wang, Y., Li, A., Zan, L., & Wang, H. (2019). Neudesin neurotrophic factor promotes bovine preadipocyte differentiation and inhibits myoblast myogenesis. Animals, 9(12), 1109.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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