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Mouse Anti-NENF Recombinant Antibody (CBWJN-1329) (CBMAB-N1968-WJ)

This product is a Mouse antibody that recognizes NENF. The antibody CBWJN-1329 can be used for immunoassay techniques such as: WB, IHC.
See all NENF antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJN-1329
Antibody Isotype
IgG2b
Application
WB, IHC

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Neudesin Neurotrophic Factor
Introduction
This gene encodes a neurotrophic factor that may play a role in neuron differentiation and development. A pseudogene of this gene is found on chromosome 12. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2009]
Entrez Gene ID
29937
UniProt ID
Q9UMX5
Alternative Names
Neudesin Neurotrophic Factor; Cell Immortalization-Related Protein 2; Secreted Protein Of Unknown Function; Neuron-Derived Neurotrophic Factor; Neudesin; CIR2; SPUF; Spinal Cord Injury Related Protein 10;
Function
Acts as a neurotrophic factor in postnatal mature neurons enhancing neuronal survival (PubMed:31536960).

Promotes cell proliferation and neurogenesis in undifferentiated neural progenitor cells at the embryonic stage and inhibits differentiation of astrocytes (By similarity).

Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways (By similarity).

Neurotrophic activity is enhanced by binding to heme (By similarity).

Acts also as an anorexigenic neurotrophic factor that contributes to energy balance (By similarity).
Biological Process
Negative regulation of appetite Source: UniProtKB
Negative regulation of neuron death Source: UniProtKB
Positive regulation of MAPK cascade Source: Ensembl
Cellular Location
Mitochondrion
Endoplasmic reticulum
Extracellular region or secreted
extracellular space
Note: Localized to mitochondria and endoplasmic reticulum by PINK1 and PARK7.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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