NET1

This gene is part of the family of Rho guanine nucleotide exchange factors. Members of this family activate Rho proteins by catalyzing the exchange of GDP for GTP. The protein encoded by this gene interacts with RhoA within the cell nucleus and may play a role in repairing DNA damage after ionizing radiation. Pseudogenes of this gene are located on the long arms of chromosomes 1, 7 and 18. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

Full Name

Neuroepithelial Cell Transforming 1

Function

Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.

Biological Process

Cellular response to hydrogen peroxide Source: UniProtKB
Cellular response to ionizing radiation Source: UniProtKB
Intracellular signal transduction Source: InterPro
Myoblast migration Source: Ensembl
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of GTPase activity Source: UniProtKB
Positive regulation of Rho protein signal transduction Source: GO_Central
Regulation of cell growth Source: UniProtKB
Regulation of small GTPase mediated signal transduction Source: Reactome
Signal transduction Source: ProtInc

Cellular Location

Nucleus
Cytoplasm