NFAT5

The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Full Name

nuclear factor of activated T-cells 5, tonicity-responsive

Function

Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Mediates the transcriptional response to hypertonicity (PubMed:10051678).

Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (PubMed:22266867).

Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (PubMed:10377394).

Biological Process

Calcineurin-NFAT signaling cascade Source: GO_Central
Cellular hyperosmotic response Source: ProtInc
Cellular response to cytokine stimulus Source: ARUK-UCL
Positive regulation of gene expression Source: Ensembl
Positive regulation of leukocyte adhesion to vascular endothelial cell Source: ARUK-UCL
Positive regulation of NIK/NF-kappaB signaling Source: ARUK-UCL
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of calcineurin-NFAT signaling cascade Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Signal transduction Source: ProtInc
Transcription by RNA polymerase II Source: ProtInc

Cellular Location

Nucleus
Cytoplasm
Note: Nuclear distribution increases under hypertonic conditions.

PTM

Phosphorylated (PubMed:10377394). Phosphorylated at Thr-135 by CDK5 in response to osmotic stress; this phosphorylation mediates its rapid nuclear localization (PubMed:21209322).