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NLRP2

NALP proteins, such as NALP2, are characterized by an N-terminal pyrin (MIM 608107) domain (PYD) and are involved in the activation of caspase-1 (CASP1; MIM 147678) by Toll-like receptors (see TLR4; MIM 603030). They may also be involved in protein complexes that activate proinflammatory caspases (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM

Full Name

NLR family, pyrin domain containing 2

Function

Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature pro-inflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of pro-inflammatory caspases.

Biological Process

Apoptotic processIEA:UniProtKB-KW
Inflammatory responseIEA:UniProtKB-KW
Innate immune responseIEA:UniProtKB-KW
Negative regulation of NF-kappaB transcription factor activityManual Assertion Based On ExperimentIGI:UniProtKB
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic processManual Assertion Based On ExperimentIDA:HGNC-UCL
Positive regulation of interleukin-1 beta productionManual Assertion Based On ExperimentIDA:HGNC-UCL

Cellular Location

Cytoplasm

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Anti-NLRP2 antibodies

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Mouse Anti-NLRP2 Recombinant Antibody (8F10B51) (CBMAB-N2689-WJ)

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Target: NLRP2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 8F10B51

Application*: WB, IF

Mouse Anti-NLRP2 Recombinant Antibody (1B10) (CBMAB-N2688-WJ)

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Target: NLRP2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 1B10

Application*: E

Mouse Anti-NLRP2 Recombinant Antibody (CBWJN-1434) (CBMAB-N2686-WJ)

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Target: NLRP2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBWJN-1434

Application*: WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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