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Mouse Anti-NLRP2 Recombinant Antibody (8F10B51) (CBMAB-N2689-WJ)

This product is a Mouse antibody that recognizes NLRP2. The antibody 8F10B51 can be used for immunoassay techniques such as: WB, IF.
See all NLRP2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
8F10B51
Antibody Isotype
IgG1, κ
Application
WB, IF

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Preservative
0.09% sodium azide
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
NLR family, pyrin domain containing 2
Introduction
This gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). Members of this gene family are thought to be important regulators of immune responses. This gene product interacts with components of the IkB kinase (IKK) complex, and can regulate both caspase-1 and NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) activity. The pyrin domain is necessary and sufficient for suppression of NF-kB activity. An allelic variant (rs147585490) has been found that is incapable of blocking the transcriptional activity of NF-kB. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]
Entrez Gene ID
55655
UniProt ID
Q9NX02
Alternative Names
NLR Family Pyrin Domain Containing 2; Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 2; PYRIN Domain And NACHT Domain-Containing Protein 1; NACHT, Leucine Rich Repeat And PYD Containing 2; PYRIN-Containing APAF1-Like Protein 2; Nucleotide-Binding Site Protein 1; PYPAF2;
Function
Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature pro-inflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of pro-inflammatory caspases.
Biological Process
Apoptotic processIEA:UniProtKB-KW
Inflammatory responseIEA:UniProtKB-KW
Innate immune responseIEA:UniProtKB-KW
Negative regulation of NF-kappaB transcription factor activityManual Assertion Based On ExperimentIGI:UniProtKB
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic processManual Assertion Based On ExperimentIDA:HGNC-UCL
Positive regulation of interleukin-1 beta productionManual Assertion Based On ExperimentIDA:HGNC-UCL
Cellular Location
Cytoplasm

Zhang, T., Xing, F., Qu, M., Yang, Z., Liu, Y., Yao, Y., & Xing, N. (2023). NLRP2 in health and disease. Immunology.

Zhang, M., Wu, Y., Gao, R., Chen, X., Chen, R., & Chen, Z. (2022). Glucagon-like peptide-1 analogs mitigate neuroinflammation in Alzheimer's disease by suppressing NLRP2 activation in astrocytes. Molecular and Cellular Endocrinology, 542, 111529.

Li, T., Li, X., Mao, R., Pan, L., Que, Y., Zhu, C., ... & Li, S. (2022). NLRP2 inhibits cell proliferation and migration by regulating EMT in lung adenocarcinoma cells. Cell Biology International, 46(4), 588-598.

Ducza, L., Szücs, P., Hegedűs, K., Bakk, E., Gajtkó, A., Wéber, I., & Holló, K. (2021). NLRP2 is overexpressed in spinal astrocytes at the peak of mechanical pain sensitivity during complete freund adjuvant-induced persistent pain. International journal of molecular sciences, 22(21), 11408.

Zhang, Q., Sun, Y., He, Z., Xu, Y., Li, X., Ding, J., ... & Hu, G. (2020). Kynurenine regulates NLRP2 inflammasome in astrocytes and its implications in depression. Brain, Behavior, and Immunity, 88, 471-481.

Rossi, M. N., Pascarella, A., Licursi, V., Caiello, I., Taranta, A., Rega, L. R., ... & Prencipe, G. (2019). NLRP2 regulates proinflammatory and antiapoptotic responses in proximal tubular epithelial cells. Frontiers in Cell and Developmental Biology, 7, 252.

Mu, J., Wang, W., Chen, B., Wu, L., Li, B., Mao, X., ... & Wang, L. (2019). Mutations in NLRP2 and NLRP5 cause female infertility characterised by early embryonic arrest. Journal of Medical Genetics, 56(7), 471-480.

Matsuoka, Y., Yamashita, A., Matsuda, M., Kawai, K., Sawa, T., & Amaya, F. (2019). NLRP2 inflammasome in dorsal root ganglion as a novel molecular platform that produces inflammatory pain hypersensitivity. Pain, 160(9), 2149-2160.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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