NRF1
This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternative splicing results in multiple transcript variants. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1. [provided by RefSeq, May 2014]
Full Name
nuclear respiratory factor 1
Function
Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.
Biological Process
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:NTNU_SB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
PTM
Phosphorylation enhances DNA binding.
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Anti-NRF1 antibodies
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CompareTarget: NRF1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 4A3
Application*: IP, WB, M
Target: NRF1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 3H3
Application*: CI, IP, WB, M
Target: NRF1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 3D4
Application*: CI, IP, WB, M
Target: NRF1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: 2G4
Application*: FC, IHC-P, WB
Target: NRF1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBAb176
Application*: WB
Target: NRF1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: D9K7R
Application*: WB, IP
Target: NRF1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: D9K6P
Application*: WB, IP, CI
Target: NRF1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-1512
Application*: E, WB
Target: NRF1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-1511
Application*: WB
Target: NRF1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: R157.1.3H3
Application*: IP, WB
Target: NRF1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: R157.1.3D4
Application*: IP, WB
Target: NRF1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJN-0569
Application*: WB, CI
Target: NRF1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJN-0502
Application*: WB
Target: NRF1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2F9
Application*: E, WB
Target: NRF1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJN-0191
Application*: WB
Target: NRF1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: CBWJN-1546
Application*: WB
Target: NRF1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBWJN-1021
Application*: WB, IP, P, F, IC
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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