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NRF1

This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternative splicing results in multiple transcript variants. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1. [provided by RefSeq, May 2014]
Full Name
nuclear respiratory factor 1
Function
Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.
Biological Process
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:NTNU_SB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
PTM
Phosphorylation enhances DNA binding.

Anti-NRF1 antibodies

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Target: NRF1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-1512
Application*: E, WB
Target: NRF1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-1511
Application*: WB
Target: NRF1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: R157.1.3H3
Application*: IP, WB
Target: NRF1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: R157.1.3D4
Application*: IP, WB
Target: NRF1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJN-0569
Application*: WB, CI
Target: NRF1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJN-0502
Application*: WB
Target: NRF1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2F9
Application*: E, WB
Target: NRF1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJN-0191
Application*: WB
Target: NRF1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: CBWJN-1546
Application*: WB
Target: NRF1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBWJN-1021
Application*: WB, IP, P, F, IC
Target: NRF1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 4A3
Application*: IP, WB, M
Target: NRF1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 3H3
Application*: CI, IP, WB, M
Target: NRF1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 3D4
Application*: CI, IP, WB, M
Target: NRF1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: 2G4
Application*: FC, IHC-P, WB
Target: NRF1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBAb176
Application*: WB
Target: NRF1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: D9K7R
Application*: WB, IP
Target: NRF1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: D9K6P
Application*: WB, IP, CI
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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