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Rabbit Anti-NRF1 Recombinant Antibody (D9K6P) (CBMAB-CP1764-LY)

The product is antibody recognizes NRF1. The antibody D9K6P immunoassay techniques such as: WB,IP,CIP.
See all NRF1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey
Clone
D9K6P
Antibody Isotype
IgG
Application
WB, IP, CIP

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala175 of human NRF1 protein.
Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
nuclear respiratory factor 1
Introduction
This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternative splicing results in multiple transcript variants. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1. [provided by RefSeq, May 2014]
Entrez Gene ID
Human4899
Mouse18181
Rat312195
Monkey701933
UniProt ID
HumanQ16656
MouseQ9WU00
RatQ62792
MonkeyH9FUZ4
Alternative Names
Nuclear Respiratory Factor 1; Alpha Palindromic-Binding Protein; ALPHA-PAL; NRF-1;
Function
Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.
Biological Process
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:NTNU_SB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
PTM
Phosphorylation enhances DNA binding.

Perez, C. M., Gong, Z., Yoo, C., Roy, D., Deoraj, A., & Felty, Q. (2024). Inhibitor of DNA Binding Protein 3 (ID3) and Nuclear Respiratory Factor 1 (NRF1) Mediated Transcriptional Gene Signatures Are Associated with the Severity of Cerebral Amyloid Angiopathy. Molecular Neurobiology, 61(2), 835-882.

Lee, Y. H., Wu, R. C., Mai, H. C., Huang, W. L., Wu, C. H., Yang, Y. L., ... & Lin, V. C. (2023). The regulatory role of nuclear Respiratory factor 1 in bladder cancer cells. Anticancer Research, 43(4), 1521-1531.

Wang, D., Wan, B., Zhang, X., Sun, P., Lu, S., Liu, C., & Zhu, L. (2022). Nuclear respiratory factor 1 promotes the growth of liver hepatocellular carcinoma cells via E2F1 transcriptional activation. BMC gastroenterology, 22(1), 198.

Wu, C. H., Hsieh, P. F., Lee, Y. H., Kuo, W. W. T., Wu, R. C. Y., Lin, Y. Y., ... & Lin, V. C. (2022). Nuclear respiratory factor 1 overexpression inhibits proliferation and migration of PC3 prostate cancer cells. Cancer Genomics & Proteomics, 19(5), 614-623.

Li, H., Niu, N., Yang, J., Dong, F., Zhang, T., Li, S., & Zhao, W. (2021). Nuclear respiratory factor 1 protects H9C2 cells against hypoxia‐induced apoptosis via the death receptor pathway and mitochondrial pathway. Cell Biology International, 45(8), 1784-1796.

Lu, Y., Ding, W., Wang, B., Wang, L., Kan, H., Wang, X., ... & Zhu, L. (2020). Positive regulation of human PINK1 and Parkin gene expression by nuclear respiratory factor 1. Mitochondrion, 51, 22-29.

Alam, C., Hoque, M. T., Sangha, V., & Bendayan, R. (2020). Nuclear respiratory factor 1 (NRF‐1) upregulates the expression and function of reduced folate carrier (RFC) at the blood‐brain barrier. The FASEB Journal, 34(8), 10516-10530.

Bhawe, K., Felty, Q., Yoo, C., Ehtesham, N. Z., Hasnain, S. E., Singh, V. P., ... & Roy, D. (2020). Nuclear respiratory factor 1 (NRF1) transcriptional activity-driven gene signature association with severity of astrocytoma and poor prognosis of glioblastoma. Molecular neurobiology, 57, 3827-3845.

Ayeleso, A. O., Adepoju, A. E., & Mukwevho, E. (2020). Nuclear respiratory factor-1 (NRF-1), a versatile therapeutic target: influence of plant metabolites. African journal of biomedical research, 23(1), 1-8.

Niu, N., Li, Z., Zhu, M., Sun, H., Yang, J., Xu, S., ... & Song, R. (2019). Effects of nuclear respiratory factor‑1 on apoptosis and mitochondrial dysfunction induced by cobalt chloride in H9C2 cells. Molecular medicine reports, 19(3), 2153-2163.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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