OTUD7B

OTUD7B (OTU Deubiquitinase 7B) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include cysteine-type peptidase activity and obsolete ubiquitin thiolesterase activity. An important paralog of this gene is OTUD7A.

Full Name

OTU Deubiquitinase 7B

Function

Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections (By similarity).
Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241).
Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity).
Mediates deubiquitination of EGFR (PubMed:22179831).
Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains (PubMed:27732584).
Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure (PubMed:27732584).
Hydrolyzes both linear and branched forms of polyubiquitin.

Biological Process

Adaptive immune responseIEA:UniProtKB-KW
In utero embryonic developmentIEA:Ensembl
Mucosal immune responseISS:UniProtKB
Negative regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentIDA:HGNC-UCL
Negative regulation of interleukin-8 productionManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Negative regulation of protein localization to nucleusManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Protein deubiquitinationTAS:Reactome
Protein deubiquitination involved in ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Protein K11-linked deubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Protein K48-linked deubiquitinationManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Protein K63-linked deubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cytoplasm
Nucleus
Shuttles be cytoplasm and the nucleus in a XPO1/CRM1-dependent manner.

PTM

Phosphorylated by EGFR.