OVGP1

This gene encodes a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoan acrosomal regions. [provided by RefSeq]

Full Name

oviductal glycoprotein 1, 120kDa

Function

Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development.

Biological Process

Carbohydrate metabolic processIEA:InterPro
Chitin catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Female pregnancyManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of binding of sperm to zona pellucidaIEA:Ensembl
Single fertilizationIEA:UniProtKB-KW

Cellular Location

Cytoplasmic vesicle, secretory vesicle
Secretory granules.