OVGP1
This gene encodes a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoan acrosomal regions. [provided by RefSeq]
Full Name
oviductal glycoprotein 1, 120kDa
Function
Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development.
Biological Process
Carbohydrate metabolic processIEA:InterPro
Chitin catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Female pregnancyManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of binding of sperm to zona pellucidaIEA:Ensembl
Single fertilizationIEA:UniProtKB-KW
Chitin catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Female pregnancyManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of binding of sperm to zona pellucidaIEA:Ensembl
Single fertilizationIEA:UniProtKB-KW
Cellular Location
Cytoplasmic vesicle, secretory vesicle
Secretory granules.
Secretory granules.
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Anti-OVGP1 antibodies
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Target: OVGP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat, Hamster
Clone: CBXO-0098
Application*: WB, E, IP, IF, P
Target: OVGP1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3F9
Application*: E, WB
Target: OVGP1
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: CBXO-0542
Application*: WB, E, IP, IF, P
Target: OVGP1
Sensitivity: 0.0088 ng/mL
Detection Range: 0.02-4 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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