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P2RY4

The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to uridine nucleotides, partially responsive to ATP, and not responsive to ADP.

Full Name

Pyrimidinergic Receptor P2Y4

Function

Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP.

Topology

Extracellular: 1-34
Helical: 35-61
Cytoplasmic: 62-72
Helical: 73-95
Extracellular: 96-112
Helical: 113-131
Cytoplasmic: 132-154
Helical: 155-174
Extracellular: 175-196
Helical: 197-222
Cytoplasmic: 223-246
Helical: 247-269
Extracellular: 270-287
Helical: 288-309
Cytoplasmic: 310-365

PTM

Phosphorylation of Ser-333 and Ser-334 is a key step in agonist-dependent desensitization and loss of surface P2RY4. This phosphorylation does not involve PKC, nor other calcium activated kinases.

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Anti-P2RY4 antibodies

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Mouse Anti-P2RY4 Recombinant Antibody (CBT2877) (V2LY-0625-LY777)

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Target: P2RY4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBT2877

Application*: WB, IH

Mouse Anti-P2RY4 Recombinant Antibody (CBT3426) (V2LY-0625-LY776)

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Target: P2RY4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBT3426

Application*: IH, IC, F

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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