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Mouse Anti-P2RY4 Recombinant Antibody (CBT3426) (V2LY-0625-LY776)

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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT3426
Antibody Isotype
IgG1
Application
IHC, ICC, FC

Basic Information

Immunogen
Purified recombinant fragment of human P2RY4 (AA: extra mix) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC-P1:200-1:1,000
ICC1:100-1:500
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Pyrimidinergic Receptor P2Y4
Entrez Gene ID
UniProt ID
Function
Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP.
Topology
Extracellular: 1-34
Helical: 35-61
Cytoplasmic: 62-72
Helical: 73-95
Extracellular: 96-112
Helical: 113-131
Cytoplasmic: 132-154
Helical: 155-174
Extracellular: 175-196
Helical: 197-222
Cytoplasmic: 223-246
Helical: 247-269
Extracellular: 270-287
Helical: 288-309
Cytoplasmic: 310-365
PTM
Phosphorylation of Ser-333 and Ser-334 is a key step in agonist-dependent desensitization and loss of surface P2RY4. This phosphorylation does not involve PKC, nor other calcium activated kinases.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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