PAICS

This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase

Bifunctional phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase catalyzing two reactions of the de novo purine biosynthetic pathway.

de novo' AMP biosynthetic processManual Assertion Based On ExperimentIDA:MGI
'de novo' IMP biosynthetic processManual Assertion Based On ExperimentIDA:MGI
'de novo' XMP biosynthetic processManual Assertion Based On ExperimentIDA:MGI
GMP biosynthetic processManual Assertion Based On ExperimentIDA:MGI
Purine nucleobase biosynthetic processManual Assertion Based On ExperimentTAS:ProtInc

cytoplasm
cytosol
extracellular exosome
membrane