PAICS

This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Full Name
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
Function
Bifunctional phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase catalyzing two reactions of the de novo purine biosynthetic pathway.
Biological Process
de novo' AMP biosynthetic processManual Assertion Based On ExperimentIDA:MGI
'de novo' IMP biosynthetic processManual Assertion Based On ExperimentIDA:MGI
'de novo' XMP biosynthetic processManual Assertion Based On ExperimentIDA:MGI
GMP biosynthetic processManual Assertion Based On ExperimentIDA:MGI
Purine nucleobase biosynthetic processManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
cytoplasm
cytosol
extracellular exosome
membrane
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Anti-PAICS antibodies

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Mouse Anti-PAICS Recombinant Antibody (4F4) (CBMAB-A6302-LY)

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Target: PAICS
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4F4
Application*: WB, E
Datasheet SDS

Mouse Anti-PAICS Recombinant Antibody (5B6) (CBMAB-P0681-YC)

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Target: PAICS
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 5B6
Application*: IF, WB
Datasheet SDS

Mouse Anti-PAICS Recombinant Antibody (2C9) (CBMAB-P0680-YC)

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Target: PAICS
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2C9
Application*: F, IC, IF, IH, WB
Datasheet SDS

Mouse Anti-PAICS Recombinant Antibody (1B4) (CBMAB-A4648-YC)

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Target: PAICS
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1B4
Application*: WB, F, IC, IF
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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