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Paip2b

Most mRNAs, except for histones, contain a 3-prime poly(A) tail. Poly(A)-binding protein enhances translation by circularizing mRNA through its interaction with the translation initiation factor EIF4G1 and the poly(A) tail. Various PABP-binding proteins regulate PABP activity, including PAIP1, a translational stimulator, and PAIP2A and PAIP2B, translational inhibitors.

Full Name

Poly(A) Binding Protein Interacting Protein 2B

Function

Inhibits translation of capped and polyadenylated mRNAs by displacing PABPC1 from the poly(A) tail.

Biological Process

Negative regulation of translationManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of translational initiationManual Assertion Based On ExperimentIDA:HGNC-UCL

Cellular Location

Cytoplasm

PTM

Ubiquitinated in vitro.

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Anti-Paip2b antibodies

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Mouse Anti-Paip2b Recombinant Antibody (E-9) (CBMAB-P0688-YC)

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Target: Paip2b

Host: Mouse

Antibody Isotype: IgG

Specificity: Mouse

Clone: E-9

Application*: WB, IP, IF, E

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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