Paip2b

Most mRNAs, except for histones, contain a 3-prime poly(A) tail. Poly(A)-binding protein enhances translation by circularizing mRNA through its interaction with the translation initiation factor EIF4G1 and the poly(A) tail. Various PABP-binding proteins regulate PABP activity, including PAIP1, a translational stimulator, and PAIP2A and PAIP2B, translational inhibitors.

Full Name

Poly(A) Binding Protein Interacting Protein 2B

Function

Inhibits translation of capped and polyadenylated mRNAs by displacing PABPC1 from the poly(A) tail.

Biological Process

Negative regulation of translationManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of translational initiationManual Assertion Based On ExperimentIDA:HGNC-UCL

Cellular Location

Cytoplasm

PTM

Ubiquitinated in vitro.

Anti-Paip2b antibodies

Mouse Anti-Paip2b Recombinant Antibody (E-9) (CBMAB-P0688-YC)

Datasheet

SDS

Target: Paip2b

Host: Mouse

Antibody Isotype: IgG

Specificity: Mouse

Clone: E-9

Application*: WB, IP, IF, E

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)