PANX1

The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties. [provided by RefSeq, Jul 2008]

Full Name

Pannexin 1

Function

Structural component of the gap junctions and the hemichannels involved in the ATP release and nucleotide permeation (PubMed:16908669, PubMed:20829356, PubMed:30918116).
May play a role as a Ca2+-leak channel to regulate ER Ca2+ homeostasis (PubMed:16908669).
Plays a critical role in oogenesis (PubMed:30918116).

Biological Process

Calcium ion transportManual Assertion Based On ExperimentIMP:UniProtKB
Cation transportManual Assertion Based On ExperimentIDA:BHF-UCL
Cell-cell signalingManual Assertion Based On ExperimentIBA:GO_Central
OogenesisIEA:UniProtKB-KW
Positive regulation of interleukin-1 alpha productionIEA:Ensembl
Positive regulation of interleukin-1 beta productionManual Assertion Based On ExperimentIDA:BHF-UCL
Response to ATPIEA:Ensembl
Response to ischemiaIEA:Ensembl

Cellular Location

Cell membrane
Cell junction, gap junction
Endoplasmic reticulum membrane

Involvement in disease

Oocyte maturation defect 7 (OOMD7):
An autosomal dominant infertility disorder due to oocyte degeneration and death, which may occur before or after fertilization.

Topology

Cytoplasmic: 1-40
Helical: 41-61
Extracellular: 62-106
Helical: 107-127
Cytoplasmic: 128-217
Helical: 218-238
Extracellular: 239-266
Helical: 267-287
Cytoplasmic: 288-426

PTM

S-nitrosylation inhibits channel currents and ATP release.
N-glycosylation may play a role in cell surface targeting (By similarity).
Exists in three glycosylation states: non-glycosylated (GLY0), high-mannose glycosylated (GLY1), and fully mature glycosylated (GLY2) (PubMed:30918116).