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PCYOX1

Prenylcysteine is released during the degradation of prenylated proteins. PCYOX1 catalyzes the degradation of prenylcysteine to yield free cysteines and a hydrophobic isoprenoid product (Tschantz et al., 1999 [PubMed 10585463]).[supplied by OMIM

Full Name

prenylcysteine oxidase 1

Function

Prenylcysteine oxidase that cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine (PubMed:10585463, PubMed:11078725, PubMed:12186880).
Only active against free prenylcysteines and not prenylcysteine residues within prenylated proteins or peptides (By similarity).
Involved in the final step in the degradation of prenylated proteins, by degrading prenylcysteines after the protein has been degraded (PubMed:10585463).

Biological Process

Chloride transmembrane transportIEA:Ensembl
Prenylated protein catabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Prenylcysteine catabolic processIEA:Ensembl

Cellular Location

Lysosome

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Anti-PCYOX1 antibodies

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Mouse Anti-PCYOX1 Recombinant Antibody (5E151) (CBMAB-P1113-YC)

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Target: PCYOX1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 5E151

Application*: E

Mouse Anti-PCYOX1 Recombinant Antibody (3D7-D8) (CBMAB-P1112-YC)

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Target: PCYOX1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 3D7-D8

Application*: E

Human PCYOX1 ELISA Kit (V2LY-0626-LY5053)

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Target: PCYOX1

Sensitivity: 0.0095 ng/mL

Detection Range: 0.02-4.5 ng/mL

Sample Type: Serum, Plasma, cell culture supernates

Specificity: Human

Assay Type: Sandwich

Reactivity: Human

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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