PDE4B

This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

Full Name

Phosphodiesterase 4B

Function

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:15260978).
May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.

Biological Process

cAMP catabolic processIEA:UniProtKB-UniPathway
Cellular response to epinephrine stimulusISS:BHF-UCL
Cellular response to lipopolysaccharideISS:BHF-UCL
Cellular response to xenobiotic stimulusISS:BHF-UCL
Leukocyte migrationISS:BHF-UCL
Negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart processIEA:Ensembl
Negative regulation of relaxation of cardiac muscleISS:BHF-UCL
Neutrophil chemotaxisISS:BHF-UCL
Neutrophil homeostasisISS:BHF-UCL
Positive regulation of interferon-gamma productionManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of interleukin-2 productionManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of cardiac muscle cell contractionISS:BHF-UCL
Regulation of high voltage-gated calcium channel activityISS:BHF-UCL
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
T cell receptor signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL

Cellular Location

Isoform PDE4B5
Cytoplasm
Cell membrane