Human Recombinant PDE4B, Active protein, GST Tag (V2LY-0526-LY6034)

Name: Human Recombinant PDE4B, Active protein, GST Tag
SKU: V2LY-0526-LY6034
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant PDE4B, Active protein, GST Tag consist of Amino Acid: 305-end and predicts a molecular mass of 78 kDa.

Molecule Mass

78 kDa

Sequence

Amino Acid: 305-end

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

Tirs, NaCl, Glycerol

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

Phosphodiesterase 4B

Function

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:15260978).
May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.

Biological Process

cAMP catabolic processIEA:UniProtKB-UniPathway
Cellular response to epinephrine stimulusISS:BHF-UCL
Cellular response to lipopolysaccharideISS:BHF-UCL
Cellular response to xenobiotic stimulusISS:BHF-UCL
Leukocyte migrationISS:BHF-UCL
Negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart processIEA:Ensembl
Negative regulation of relaxation of cardiac muscleISS:BHF-UCL
Neutrophil chemotaxisISS:BHF-UCL
Neutrophil homeostasisISS:BHF-UCL
Positive regulation of interferon-gamma productionManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of interleukin-2 productionManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of cardiac muscle cell contractionISS:BHF-UCL
Regulation of high voltage-gated calcium channel activityISS:BHF-UCL
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
T cell receptor signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL

Cellular Location

Isoform PDE4B5
Cytoplasm
Cell membrane

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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