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Mouse Anti-PDE4B Recombinant Antibody (3A10) (CBMAB-P1214-YC)

Provided herein is a Mouse monoclonal antibody against Human Phosphodiesterase 4B. The antibody can be used for immunoassay techniques, such as FC, IHC-P, WB.
See all PDE4B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3A10
Antibody Isotype
IgG1
Application
FC, IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Phosphodiesterase 4B
Introduction
PDE4B is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms.
Entrez Gene ID
5142
UniProt ID
Q07343
Alternative Names
Phosphodiesterase 4B; Phosphodiesterase 4B, CAMP-Specific (Phosphodiesterase E4 Dunce Homolog, Drosophila); CAMP-Specific 3,5-Cyclic Phosphodiesterase 4B; DPDE4; Phosphodiesterase 4B, CAMP-Specific (Dunce (Drosophila)-Homolog Phosphodiesterase E4); Phosphodiesterase E4 Dunce Homolog (Drosophila); Phosphodiesterase 4B, CAMP-Specific;
Function
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:15260978).
May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.
Biological Process
cAMP catabolic processIEA:UniProtKB-UniPathway
Cellular response to epinephrine stimulusISS:BHF-UCL
Cellular response to lipopolysaccharideISS:BHF-UCL
Cellular response to xenobiotic stimulusISS:BHF-UCL
Leukocyte migrationISS:BHF-UCL
Negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart processIEA:Ensembl
Negative regulation of relaxation of cardiac muscleISS:BHF-UCL
Neutrophil chemotaxisISS:BHF-UCL
Neutrophil homeostasisISS:BHF-UCL
Positive regulation of interferon-gamma productionManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of interleukin-2 productionManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of cardiac muscle cell contractionISS:BHF-UCL
Regulation of high voltage-gated calcium channel activityISS:BHF-UCL
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
T cell receptor signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Cellular Location
Isoform PDE4B5
Cytoplasm
Cell membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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